Emerging Role of Non-Coding RNAs in Aortic Dissection.
Emerging Role of Non-Coding RNAs in Aortic Dissection.
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DOI：
10.3390/biom12101336
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发表时间：
2022-09-21
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
主动脉夹层（Aortic dissection，AD）是一种发病率和死亡率都很高的致死性心血管急症，严重威胁着患者的生命和健康。AD的发病机制主要包括血管炎症、细胞外基质降解、血管平滑肌细胞（VSMCs）表型转化和凋亡，但其具体机制尚未完全阐明。非编码RNA（Non-coding RNA，ncRNA）包括microRNA（microRNA，miRNAs）、长链非编码RNA（longnon-coding RNA，lncRNA）和环状RNA（circRNA，circRNA），是一类新兴的不具有蛋白质编码能力的RNA分子，它们在包括AD在内的许多疾病的进展中起着至关重要的作用。越来越多的研究表明，ncRNA的异常调控通过调节特定靶基因的表达或相关蛋白的活性，参与AD的发生和发展。此外，一些ncRNA在AD治疗中显示出巨大的潜力作为有前途的生物标志物和治疗靶点。本文就ncRNA参与AD调控的机制及其作为AD生物标志物和治疗靶点的临床应用作一综述。本文综述的信息将对基于ncRNA的AD患者治疗策略的发展大有裨益。
Aortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and mortality, and it seriously threatens patients’ lives and health. The pathogenesis of AD mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of vascular smooth muscle cells (VSMCs); however, its detailed mechanisms are still not fully elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are an emerging class of RNA molecules without protein-coding ability, and they play crucial roles in the progression of many diseases, including AD. A growing number of studies have shown that the dysregulation of ncRNAs contributes to the occurrence and development of AD by modulating the expression of specific target genes or the activity of related proteins. In addition, some ncRNAs exhibit great potential as promising biomarkers and therapeutic targets in AD treatment. In this review, we systematically summarize the recent findings on the underlying mechanism of ncRNA involved in AD regulation and highlight their clinical application as biomarkers and therapeutic targets in AD treatment. The information reviewed here will be of great benefit to the development of ncRNA-based therapeutic strategies for AD patients.
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