Roles for neuronal and glial autophagy in synaptic pruning during development.
Roles for neuronal and glial autophagy in synaptic pruning during development.
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DOI：
10.1016/j.nbd.2018.04.017
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发表时间：
2019-03
影响因子：
6.1
通讯作者：
Sulzer D
中科院分区：
文献类型：
--
作者：
Lieberman OJ;McGuirt AF;Tang G;Sulzer D
称为棘的树突状突起代表兴奋性突触的主要突触后位置。树突棘对于突触功能至关重要，并且它们的形成、修饰和周转被认为对于学习和记忆机制是重要的。在许多突触中，树突棘在出生后早期形成，虽然许多棘可能在一生中形成和移除，但净数量通常在青春期逐渐“修剪”，以达到成年后的稳定水平。在神经发育障碍中，脊柱修剪被破坏，强调了解脊柱修剪过程的重要性。自噬是细胞溶质成分和细胞器降解的一个过程，最近已被证明可以控制小鼠皮层中的棘修剪，但是自噬作用的机制仍然不清楚。在这里，我们借鉴了三个研究充分的原型突触修剪事件，专注于脊修剪的两个主导原则：1）活动依赖性突触竞争和2）非神经元的贡献。我们简要回顾了已知的自噬在中枢神经系统和它的调节代谢激酶。然后，我们提出了一个模型，其中神经元和非神经元细胞中的自噬有助于脊柱修剪，以及调节脊柱修剪的其他过程如何与自噬交叉。我们进一步概述了未来的研究方向，以解决悬而未决的问题，在突触修剪的作用自噬。
The dendritic protrusions known as spines represent the primary postsynaptic location for excitatory synapses. Dendritic spines are critical for synaptic function, and their formation, modification, and turnover are thought to be important for mechanisms of learning and memory. At many synapses, dendritic spines form during the early postnatal period, and while many spines are likely being formed and removed throughout life, the net number are often gradually “pruned” during adolescence to reach a stable level in the adult. In neurodevelopmental disorders, spine pruning is disrupted, emphasizing the importance of understanding the processes governing spine pruning. Autophagy, a process through which cytosolic components and organelles are degraded, has recently been shown to control spine pruning in the mouse cortex, but, the mechanisms through which autophagy acts remain obscure. Here, we draw on three well-studied prototypical synaptic pruning events to focus on two governing principles of spine pruning: 1) activity-dependent synaptic competition and 2) non-neuronal contributions. We briefly review what is known about autophagy in the central nervous system and its regulation by metabolic kinases. We then propose a model in which autophagy in both neurons and non-neuronal cells contributes to spine pruning, and how other processes that regulate spine pruning could intersect with autophagy. We further outline future research directions to address outstanding questions on the role of autophagy in synaptic pruning.
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影响因子：
5.7
作者：
Anggono V;Huganir RL
通讯作者：
Huganir RL
DOI：
10.1083/jcb.201401070
发表时间：
2014-09-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ashrafi G;Schlehe JS;LaVoie MJ;Schwarz TL
通讯作者：
Schwarz TL
影响因子：
6.1
作者：
Chevere-Torres, Itzamarie;Kaphzan, Hanoch;Bhattacharya, Aditi;Kang, Areum;Maki, Jordan M.;Gambello, Michael J.;Arbiser, Jack L.;Santini, Emanuela;Klann, Eric
通讯作者：
Klann, Eric
影响因子：
3.5
作者：
Cariboni, Anna;Davidson, Kathryn;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana
影响因子：
2.5
作者：
ALTMAN, J
通讯作者：
ALTMAN, J