High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients.
High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients.
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DOI：
10.3389/fonc.2020.563666
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发表时间：
2020
影响因子：
4.7
通讯作者：
Liu P
中科院分区：
文献类型：
--
作者：
Sun Y;Xu Z;Jiang J;Xu T;Xu J;Liu P
大多数多发性骨髓瘤（MM）患者最终会复发，目前的治疗效果有限。在此，我们证明琥珀酸脱氢酶亚单位A（SDHA）在MM患者中低表达，SDHA相对高表达的患者具有较长的总生存期和无进展生存期。此外，SDHA高表达可抑制MM细胞系的增殖和侵袭，增强化疗药物的抗肿瘤和协同作用。更重要的是，西达米特通过靶向SDHA而被证明在MM中是有效的，并且西达米特通过乙酰化SDHA的H3K27位点来增加SDHA的表达。SDHA的高表达受组蛋白乙酰化调控，并被西达米特靶向，可能成为MM患者良好的预后因子。
Most patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunit A (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progression-free survival. Furthermore, SDHA high expression inhibited proliferation and invasion in MM cell lines and enhanced the anti-tumor and synergistic effect of chemotherapeutics. More importantly, chidamide was proved effective in MM by targeting SDHA, and expression of SDHA was increased by chidamide through acetylating H3K27 site of SDHA. Collectively, high expression of SDHA, which was regulated by histone acetylation and targeted by chidamide, might become a good prognostic factor of MM patients.
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影响因子：
8.8
作者：
Bruyer A;Maes K;Herviou L;Kassambara A;Seckinger A;Cartron G;Rème T;Robert N;Requirand G;Boireau S;Müller-Tidow C;Veyrune JL;Vincent L;Bouhya S;Goldschmidt H;Vanderkerken K;Hose D;Klein B;De Bruyne E;Moreaux J
通讯作者：
Moreaux J
影响因子：
3.2
作者：
Dupéré-Richer D;Licht JD
通讯作者：
Licht JD
慢性淋巴细胞白血病中 TNFα 诱导的坏死性凋亡信号失调：LEF1 抑制 CYLD 基因
影响因子：
11.4
作者：
Liu, P.;Xu, B.;Li, J.
通讯作者：
Li, J.
影响因子：
11.4
作者：
通讯作者：
--
DOI：
10.1016/j.bbrc.2010.01.011
发表时间：
2010-02-05
影响因子：
3.1
作者：
Liu, Lin;Chen, Baoan;Zhao, Hong
通讯作者：
Zhao, Hong