Bidirectional longitudinal associations between loneliness and pain, and the role of inflammation.
Bidirectional longitudinal associations between loneliness and pain, and the role of inflammation.
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DOI：
10.1097/j.pain.0000000000002082
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发表时间：
2021-03-01
期刊：
影响因子：
7.4
通讯作者：
Steptoe A
中科院分区：
文献类型：
--
作者：
Loeffler A;Steptoe A
补充数字内容可在正文中找到。在4906名老年男性和女性的样本中，观察了4年期间孤独和疼痛之间的双向联系。痛苦和孤独始终如一地联系在一起，但关系的方向是不确定的。我们评估了4906名男性和女性(平均65.1±8.72岁)在4年时间里的双向关联，他们是英国老龄化纵向研究的参与者。炎症在这些环节中的作用也被研究了。疼痛的定义是通过报告经常被中等或严重强度的疼痛所困扰，而孤独是使用缩短的加州大学洛杉矶分校量表来衡量的。年龄、性别、种族、教育程度、财富作为社会经济资源的标志、婚姻状况、体力活动和抑郁症状被包括在协变量中。我们发现，在调整了基线疼痛和其他协变量后，基线孤独与4年后的疼痛相关(优势比[OR]=1.25，95%可信区间[CI]1.06-1.47，P=0.007)。同样，基线疼痛独立预测4年后的孤独感(OR=1.34，95%CI1.14~1.58，P=0.001)。在对基线活动障碍进行额外调整后，相关性仍然显著。当基线孤独伴随C反应蛋白浓度升高(OR=1.5，95%CI1.13~2.00，P=0.006)时，随访时疼痛的可能性增加，而炎症不能预测未来的孤独，也不能促进基线疼痛与未来孤独之间的关联。痛苦和孤独都是影响幸福和生活质量的痛苦经历。我们的结论是，在这个具有代表性的老年男性和女性样本中，疼痛和孤独之间存在双向的纵向关系，但这些过程背后的机制可能不同。
Supplemental Digital Content is Available in the Text. Bidirectional associations between loneliness and pain over a 4-year period were observed in a sample of 4906 older men and women. Pain and loneliness are consistently associated, but the direction of the relationship is uncertain. We assessed bidirectional associations over a 4-year period in a sample of 4906 men and women (mean 65.1 ± 8.72 years) who were participants in the English Longitudinal Study of Ageing. The role of inflammation in these links was also investigated. Pain was defined by reports of being often troubled by pain at a moderate or severe intensity, whereas loneliness was measured using the shortened UCLA scale. Age, sex, ethnicity, educational attainment, wealth as a marker of socioeconomic resources, marital status, physical activity, and depressive symptoms were included as covariates. We found that baseline loneliness was associated with pain 4 years later after adjusting for baseline pain and other covariates (odds ratio [OR] = 1.25, 95% confidence interval [CI] 1.06-1.47, P = 0.007). Similarly, baseline pain independently predicted loneliness 4 years later (OR = 1.34, 95% CI 1.14-1.58, P = 0.001). Associations remained significant after additional adjustment for baseline mobility impairment. Likelihood of pain on follow-up was heightened when baseline loneliness was accompanied by elevated C-reactive protein concentration (OR = 1.50, 95% CI 1.13-2.00, P = 0.006), whereas inflammation did not predict future loneliness or contribute to the association between baseline pain and future loneliness. Both pain and loneliness are distressing experiences that impact well-being and quality of life. We conclude that there were bidirectional longitudinal relationships between pain and loneliness in this representative sample of older men and women, but that the mechanisms underlying these processes may differ.
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影响因子：
6.3
作者：
Demakakos, Panayotes;Biddulph, Jane P.;Marmot, Michael G.
通讯作者：
Marmot, Michael G.
影响因子：
2.7
作者：
Boggero, Ian A.;Sturgeon, John A.;Segerstrom, Suzanne C.
通讯作者：
Segerstrom, Suzanne C.
影响因子：
2.6
作者：
Hughes, ME;Waite, LJ;Cacioppo, JT
通讯作者：
Cacioppo, JT
DOI：
10.1093/abm/kay017
发表时间：
2019-01-01
期刊：
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
影响因子：
--
作者：
Karayannis NV;Baumann I;Sturgeon JA;Melloh M;Mackey SC
通讯作者：
Mackey SC
影响因子：
3.7
作者：
Hackett, Ruth A.;Hamer, Mark;Steptoe, Andrew
通讯作者：
Steptoe, Andrew