Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors.
Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors.
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DOI：
10.3389/fnins.2018.00084
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发表时间：
2018
影响因子：
4.3
通讯作者：
Pellegrini E
中科院分区：
文献类型：
--
作者：
Diotel N;Charlier TD;Lefebvre d'Hellencourt C;Couret D;Trudeau VL;Nicolau JC;Meilhac O;Kah O;Pellegrini E
性类固醇激素是由胆固醇合成的，在中枢神经系统中具有显著的多效性作用。Baulieu及其同事的开创性研究表明，类固醇也在大脑中局部合成。这种类固醇，称为神经类固醇，可以迅速调节神经元的兴奋性和功能，大脑的可塑性和行为。在各种物种上获得的累积数据表明，神经类固醇生成是鱼类、鸟类和哺乳动物的进化保守特征。在这篇综述中，我们将首先记录硬骨鱼，鸟类和哺乳动物大脑中雌激素，孕激素和雄激素的神经类固醇生成和类固醇信号。接下来我们将讨论性类固醇在体内平衡和再生神经发生、神经保护和性行为中的作用。在最后一部分中，我们将讨论类固醇和脂蛋白从脑内外周的转运（反之亦然），并记录它们对血脑屏障（BBB）通透性和神经保护的影响。我们将强调脂蛋白和性类固醇之间的潜在相互作用，解决类固醇和脂蛋白，特别是高密度脂蛋白胆固醇，对脑缺血性中风期间发生的BBB的崩溃报告的有益影响。因此，我们将强调性类固醇和脂蛋白的潜在抗炎，抗氧化和神经保护特性，这些最新的改善脑内胆固醇和类固醇酯运输后的侮辱。
Sex steroid hormones are synthesized from cholesterol and exert pleiotropic effects notably in the central nervous system. Pioneering studies from Baulieu and colleagues have suggested that steroids are also locally-synthesized in the brain. Such steroids, called neurosteroids, can rapidly modulate neuronal excitability and functions, brain plasticity, and behavior. Accumulating data obtained on a wide variety of species demonstrate that neurosteroidogenesis is an evolutionary conserved feature across fish, birds, and mammals. In this review, we will first document neurosteroidogenesis and steroid signaling for estrogens, progestagens, and androgens in the brain of teleost fish, birds, and mammals. We will next consider the effects of sex steroids in homeostatic and regenerative neurogenesis, in neuroprotection, and in sexual behaviors. In a last part, we will discuss the transport of steroids and lipoproteins from the periphery within the brain (and vice-versa) and document their effects on the blood-brain barrier (BBB) permeability and on neuroprotection. We will emphasize the potential interaction between lipoproteins and sex steroids, addressing the beneficial effects of steroids and lipoproteins, particularly HDL-cholesterol, against the breakdown of the BBB reported to occur during brain ischemic stroke. We will consequently highlight the potential anti-inflammatory, anti-oxidant, and neuroprotective properties of sex steroid and lipoproteins, these latest improving cholesterol and steroid ester transport within the brain after insults.
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影响因子：
4.7
作者：
Balazs, Z;Panzenboeck, U;Sattler, W
通讯作者：
Sattler, W
影响因子：
4.8
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3.2
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3
作者：
Axelsson, Jeanette;Mattsson, Anna;Halldin, Krister
通讯作者：
Halldin, Krister
影响因子：
3.5
作者：
BALTHAZART, J;EVRARD, L;SURLEMONT, C
通讯作者：
SURLEMONT, C