Composition and conservation of the mRNA-degrading machinery in bacteria.
Composition and conservation of the mRNA-degrading machinery in bacteria.
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DOI:
10.1186/1423-0127-18-23
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发表时间:
2011-03-22
影响因子:
11
通讯作者:
Lin-Chao S
中科院分区:
文献类型:
--
作者:
Kaberdin VR;Singh D;Lin-Chao S
RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.
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通讯作者:
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Hasnain, Seyed E.
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