Composition and conservation of the mRNA-degrading machinery in bacteria.

Composition and conservation of the mRNA-degrading machinery in bacteria.
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DOI:
10.1186/1423-0127-18-23
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发表时间:
2011-03-22
影响因子:
11
通讯作者:
Lin-Chao S
Lin-Chao S
中科院分区:
医学1区
文献类型:
--
作者:
Kaberdin VR;Singh D;Lin-Chao S

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RNA合成和衰变相互抵消,因此通过控制个体转录物的稳态水平来反向调节原核和真核细胞中的基因表达。遗传和生化数据以及最近对细菌基因组的深入注释表明,细菌RNA衰变机制的许多组成部分在进化上是保守的,它们的功能类似物存在于属于所有生命王国的生物体中。本文简要介绍了大肠杆菌中必需酶的生物学功能、它们的进化保守性和参与mRNA衰变的多酶复合物,并讨论了它们在进化上遥远的细菌中的保守性。
RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.
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