A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group.
A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group.
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用于粪便微生物群移植的粪便银行的标准化模型：多学科UEG工作组的共识报告。
DOI：
10.1177/2050640620967898
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发表时间：
2021-03
影响因子：
6
通讯作者：
Vehreschild MJGT
中科院分区：
文献类型：
--
作者：
Keller JJ;Ooijevaar RE;Hvas CL;Terveer EM;Lieberknecht SC;Högenauer C;Arkkila P;Sokol H;Gridnyev O;Mégraud F;Kump PK;Nakov R;Goldenberg SD;Satokari R;Tkatch S;Sanguinetti M;Cammarota G;Dorofeev A;Gubska O;Ianiro G;Mattila E;Arasaradnam RP;Sarin SK;Sood A;Putignani L;Alric L;Baunwall SMD;Kupcinskas J;Link A;Goorhuis AG;Verspaget HW;Ponsioen C;Hold GL;Tilg H;Kassam Z;Kuijper EJ;Gasbarrini A;Mulder CJJ;Williams HRT;Vehreschild MJGT
粪便微生物区系移植是一种新兴的治疗选择，特别是对难治性梭状芽胞杆菌反复感染的治疗。组织招募和筛选粪便捐赠者的粪便库被嵌入到欧盟组织和细胞指令以及欧洲理事会出版的组织和细胞质量和安全技术指南中描述的监管框架中。欧洲和国际上发表了一些关于粪便微生物区系移植的共识声明。虽然这些文件提供了总体指导，但我们的目标是在本文件中提供与人类供体粪便的收集、处理和临床应用相关的所有过程的详细描述。粪便银行问题专家协作小组起草了与粪便银行有关的所有领域的概念。在巴塞罗那举行的2019年联合欧洲胃肠病学周的一次工作组会议上，讨论并最终确定了这些概念，并将其纳入我们关于粪便微生物区系移植的总体指导文件。为与粪便银行有关的所有领域创建了一份指导文件。本文件包括与粪便储存有关的几个流程的标准操作手册，如捐赠者材料的处理、储存和捐赠者筛选。根据我们的指导文件，由粪便银行实施粪便微生物区系移植，将确保质量保证，并保证为患者提供供体粪便制剂。
Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of faeces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council. Several European and international consensus statements concerning faecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document. Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about faecal microbiota transplantation. A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening. The implementation of faecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor faeces preparations for patients.
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影响因子：
14.2
作者：
Debast, S. B.;Bauer, M. P.;Kuijper, E. J.
通讯作者：
Kuijper, E. J.
影响因子：
24.5
作者：
El-Salhy, Magdy;Hatlebakk, Jan Gunnar;Hausken, Trygve
通讯作者：
Hausken, Trygve
影响因子：
2.6
作者：
Alrabaa, Sally;Jariwala, Ripal;Montero, Jose
通讯作者：
Montero, Jose
影响因子：
--
作者：
Emanuelsson, Frida;Claesson, Berndt E. B.;Ung, Kjell-Arne
通讯作者：
Ung, Kjell-Arne
影响因子：
4
作者：
Dailey, Francis E.;Turse, Erica P.;Tahan, Veysel
通讯作者：
Tahan, Veysel