Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study.
Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study.
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DOI：
10.1136/bmjopen-2017-020681
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发表时间：
2018-08-23
期刊：
影响因子：
2.9
通讯作者：
Jiang Y
中科院分区：
文献类型：
--
作者：
Yang X;Lv H;Hidru TH;Wu J;Liu H;Wang Y;Liu K;Xia Y;Zhou Y;Jiang Y
血清尿酸（SUA）与心血管疾病（包括动脉粥样硬化和颈动脉狭窄）有关。然而，关于SUA水平与近端颅外动脉狭窄（PEAS）之间关系的数据有限。因此，本研究探讨了中国无症状人群中SUA水平与PEAS风险之间的关系。这项基于社区的横断面研究于2013年7月至2014年8月在中国河北省唐山市冀东社区医院进行。该研究检查了3325名无症状参与者（40-60岁），以评估PEAS的风险。对于根据性别特异性SUA水平分为四分位数的参与者，PEAS的患病率从Q1增加到Q4，椎动脉（VA）从12.3%增加到29.8%，颈总动脉从2.8%增加到5.8%。Q1中PEAS相对于检测到的动脉狭窄数量的比例低于Q2-Q4。与动脉狭窄的最低四分位数相比，第二至第四位PEAS的多变量OR和95%CI为1.278（0.980至1.665）、1.117（0.851至1.468）和1.375（1.033至1.830）（p趋势=0.0399）; VA狭窄，1.285（0.966至1.709）、1.085（0.808至1.457）和1.439（1.061至1.952）（p趋势=0.0235）。在无症状的中年中国人群中，SUA浓度升高与PEAS显著相关，椎动脉似乎是最脆弱的血管。
Serum uric acid (SUA) has been associated with cardiovascular diseases, including atherosclerosis and carotid artery stenosis. However, data on the relationship between SUA level and proximal extracranial artery stenosis (PEAS) are limited. Therefore, this study investigates the association between SUA levels and the risk of PEAS in asymptomatic Chinese population. This community-based cross-sectional study was conducted in Jidong Community Hospital, Tangshan, Hebei, China between July 2013 and August 2014. The study examined 3325 asymptomatic participants (40–60 years) to evaluate the risk of PEAS. For the participants stratified into quartiles based on gender-specific SUA levels, the prevalence of PEAS increased from Q1 to Q4 from 12.3% to 29.8% in the vertebral artery (VA), and from 2.8% to 5.8% in the common carotid artery. The proportion of PEAS relative to the detected number of arterial stenosis was lower in Q1 than in Q2–Q4. The multivariable ORs and 95% CI of PEAS in the second through fourth compared with the lowest quartiles for arterial stenosis were 1.278 (0.980 to 1.665), 1.117 (0.851 to 1.468) and 1.375 (1.033 to 1.830) (ptrend=0.0399); and for VA stenosis, 1.285 (0.966 to 1.709), 1.085 (0.808 to 1.457) and 1.439 (1.061 to 1.952) (ptrend=0.0235). Elevated SUA concentration is significantly associated with PEAS in an asymptomatic middle-aged Chinese population, and vertebral arteries appeared to be the most vulnerable vessels.
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影响因子：
37.8
作者：
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通讯作者：
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