A modified two-process Knox test for investigating the relationship between law enforcement opioid seizures and overdoses

A modified two-process Knox test for investigating the relationship between law enforcement opioid seizures and overdoses
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改进的两过程诺克斯测试,用于调查执法阿片类药物缉获和过量之间的关系

DOI:
10.1098/rspa.2021.0195
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发表时间:
2021
期刊:
Physical and Engineering Sciences
影响因子:
--
通讯作者:
Flaxman, S.
Flaxman, S.
中科院分区:
--
文献类型:
--
作者:
Mohler, G.;Mishra, S.;Ray, B.;Magee, L.;Huynh, P.;Canada, M.;O’Donnell, D.;Flaxman, S.

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最近的研究表明,每月执法药物缉获事件和意外药物过量死亡之间存在关联,使用单一州的横截面数据,其中缉获量增加与更多死亡相关。在这项研究中,我们对执法药物缉获的街道级数据进行统计分析,沿着致命和非致命过量事件的街道级数据,以确定阿片类药物相关药物缉获和过量之间可能的微观因果关系。为此,我们引入了一种新的,修改后的两个过程诺克斯测试,控制自激测量聚集在执法缉获后的空间和时间附近的过量。我们观察到一个小的,但统计学显著(p< 0.001),效果17.7过量的非致命性药物过量每1000执法扣押在三周内和扣押250米。我们沿着讨论了这种关联的潜在因果机制以及政策含义。
Recent research has shown an association between monthly law enforcement drug seizure events and accidental drug overdose deaths using cross-sectional data in a single state, whereby increased seizures correlated with more deaths. In this study, we conduct statistical analysis of street-level data on law enforcement drug seizures, along with street-level data on fatal and non-fatal overdose events, to determine possible micro-level causal associations between opioid-related drug seizures and overdoses. For this purpose, we introduce a novel, modified two-process Knox test that controls for self-excitation to measure clustering of overdoses nearby in space and time following law enforcement seizures. We observe a small, but statistically significant (p< 0.001), effect of 17.7 excess non-fatal overdoses per 1000 law enforcement seizures within three weeks and 250 m of a seizure. We discuss the potential causal mechanism for this association along with policy implications.
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