Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.
Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.
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DOI：
10.3390/ijerph181910215
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发表时间：
2021-09-28
影响因子：
--
通讯作者：
Washio Y
中科院分区：
文献类型：
--
作者：
Isaacs KR;Atreyapurapu S;Alyusuf AH;Ledgerwood DM;Finnegan LP;Chang KHK;Ma TX;Washio Y
背景资料：大多数患有阿片类药物使用障碍（OUD）的孕妇也吸烟，但很少提供戒烟咨询。虽然在子宫内暴露于阿片类药物和尼古丁的影响分别得到了很好的理解，但缺乏对合并暴露于这些物质对新生儿结局的影响的理解。研究方法：使用PubMed和Scopus数据库对1980年1月1日至2019年7月9日期间发表的关于妊娠期间阿片类药物和尼古丁联合暴露的研究进行了范围审查。共有29篇论文符合入选标准，其中9篇被确定为临床试验（3篇来自MOTHER研究），2篇作为临床试验数据的次要数据分析。结果如下：在子宫内联合暴露于阿片类药物和尼古丁的婴儿的新生儿结局表明出生体重和出生身长减少。与暴露于尼古丁和阿片类药物的婴儿相比，暴露于尼古丁和阿片类药物的婴儿在新生儿戒断综合征（NAS）的持续时间、治疗NAS的可能性、用于治疗NAS的药物剂量以及NAS评分方面的结果好坏参半。尼古丁。结论：与单独使用阿片类药物相比，妊娠期间联合暴露于尼古丁和阿片类药物可能会导致新生儿出生体重和出生长度减少以及更严重的NAS体征，但需要更多的研究来确定尼古丁暴露的最小剂量和长度，以准确预测这些结果。
Background: The majority of women who are pregnant with opioid use disorder (OUD) also smoke tobacco but are rarely offered tobacco cessation counseling. While the effects of exposure to opioids and nicotine in utero are well-understood separately, understanding the impact of the combined exposure to these substances on neonatal outcomes is lacking. Methods: A scoping review was conducted using PubMed and Scopus databases for studies addressing the combined exposure to opioids and nicotine during pregnancy published between 1 January 1980 and 9 July 2019. A total of 29 papers met the eligibility criteria for inclusion, with nine being identified as clinical trials (three from the MOTHER study) and two as secondary data analysis of clinical trial data. Results: Neonatal outcomes for infants who had a combined exposure to opioids and nicotine in utero indicated a reduction in birth weight and birth length. Findings in infants exposed to both nicotine and opioids were mixed with regard to the duration of neonatal abstinence syndrome (NAS), the likelihood of treatment for NAS, doses of medicine used to treat NAS, and NAS scores when compared with infants who had opioid exposure without nicotine. Conclusions: The combined exposure to nicotine and opioids during pregnancy may lead to a reduction in neonatal birth weight and birth length and more severe NAS signs, compared with opioid use alone, but more research is necessary to identify the minimum dosage and length of nicotine exposure to accurately predict these outcomes.
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影响因子：
6.7
作者：
Forray A;Foster D
通讯作者：
Foster D
美沙酮，可卡因，阿片类药物和代谢物处置以及与母美沙酮剂量和新生儿结局相关的相关性。
影响因子：
2.5
作者：
de Castro A;Jones HE;Johnson RE;Gray TR;Shakleya DM;Huestis MA
通讯作者：
Huestis MA
影响因子：
2.1
作者：
Holbrook AM;Kaltenbach KA
通讯作者：
Kaltenbach KA
影响因子：
6.4
作者：
Baas, Jeroen;Schotten, Michiel;Karimi, Reza
通讯作者：
Karimi, Reza
影响因子：
6
作者：
Cleary, Brian J.;Eogan, Maeve;Murphy, Deirdre J.
通讯作者：
Murphy, Deirdre J.