Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles and clinical characteristics at baseline and 3-years.
Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles and clinical characteristics at baseline and 3-years.
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DOI：
10.1016/j.joca.2013.08.004
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发表时间：
2013-11
影响因子：
7
通讯作者：
Dziedzic, K.
中科院分区：
文献类型：
--
作者：
Marshall, M.;Peat, G.;Nicholls, E.;van der Windt, D.;Myers, H.;Dziedzic, K.
比较症状性手骨关节炎（OA）亚组的人群患病率、相互关系、风险因素特征和临床特征，以了解其相对频率和独特性。招募了1076名患有手部症状的社区成年人（60%为女性，平均年龄64.7岁），并使用体检和标准化手部X光照片将其分类到预定义的子集中，并使用Kellgren & Lawrence（K&L）和Verbruggen-Veys评分系统进行评分。通过直接测量（体重指数（BMI））、自填问卷（过度用手、既往手部损伤）和病历审查（高血压、血脂异常、2型糖尿病）获得选定风险因素的详细信息。在基线和3年随访时使用澳大利亚/加拿大骨关节炎手部指数（AUSCAN）自我报告手部疼痛和残疾。50岁及以上成人人群中症状性手部OA子集的粗略人群患病率估计值为：拇指基底OA（22.4%）、结节性指间关节（IPJ）OA（15.5%）、全身性手部OA（10.4%）、非结节性IPJ OA（4.9%）、糜烂性OA（1.0%）。除了拇指基部OA外，亚组之间存在相当大的重叠。在基线和3年时，EEOA表现出最明显的女性：男性比例最高，残疾最多。在该亚组中观察到肥胖、高血压、血脂异常和代谢综合征的发生率较高。手部OA亚群的重叠发生对追求不同的表型提出了概念和实践挑战。尽管如此，ECONOA可能提供了代谢和心血管危险因素在OA发病机制中的作用的特别见解。
To compare the population prevalence, inter-relationships, risk factor profiles and clinical characteristics of subsets of symptomatic hand osteoarthritis (OA) with a view to understanding their relative frequency and distinctiveness. 1076 community-dwelling adults with hand symptoms (60% women, mean age 64.7 years) were recruited and classified into pre-defined subsets using physical examination and standardised hand radiographs, scored with the Kellgren & Lawrence (K&L) and Verbruggen–Veys grading systems. Detailed information on selected risk factors was obtained from direct measurement (Body Mass Index (BMI)), self-complete questionnaires (excessive use of hands, previous hand injury) and medical record review (hypertension, dyslipidaemia, type 2 diabetes). Hand pain and disability were self-reported at baseline and 3-year follow-up using Australian/Canadian Osteoarthritis Hand Index (AUSCAN). Crude population prevalence estimates for symptomatic hand OA subsets in the adult population aged 50 years and over were: thumb base OA (22.4%), nodal interphalangeal joint (IPJ) OA (15.5%), generalised hand OA (10.4%), non-nodal IPJ OA (4.9%), erosive OA (1.0%). Apart from thumb base OA, there was considerable overlap between the subsets. Erosive OA appeared the most distinctive with the highest female: male ratio, and the most disability at baseline and 3-years. A higher frequency of obesity, hypertension, dyslipidaemia, and metabolic syndrome was observed in this subset. Overlap in the occurrence of hand OA subsets poses conceptual and practical challenges to the pursuit of distinct phenotypes. Erosive OA may nevertheless provide particular insight into the role of metabolic and cardiovascular risk factors in the pathogenesis of OA.
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影响因子：
27.4
作者：
Bijsterbosch, J.;van Bemmel, J. M.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
27.4
作者：
Haugen IK;Felson DT;Englund M;Wang K;Aliabadi P;Guermazi A;Roemer FW;Neogi T
通讯作者：
Neogi T
影响因子：
27.4
作者：
Bijsterbosch, J.;Watt, I.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
27.4
作者：
Botha-Scheepers, S.;Riyazi, N.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
5.5
作者：
Dziedzic, K.;Thomas, E.;Croft, P. R.
通讯作者：
Croft, P. R.