The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study.
The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study.
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DOI：
10.1136/annrheumdis-2012-201659
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发表时间：
2012-10
影响因子：
27.4
通讯作者：
Neogi T
中科院分区：
文献类型：
--
作者：
Haugen IK;Felson DT;Englund M;Wang K;Aliabadi P;Guermazi A;Roemer FW;Neogi T
目的：探讨侵蚀性手部骨关节炎(OA)是否与膝关节软骨下骨磨损(SBA)和全身骨密度(BMD)相关。在1253名Framingham参与者中，使用Logistic回归和广义估计方程评估了MRI定义的膝关节SBA与放射学侵蚀性手骨关节炎之间的关系。我们还研究了侵蚀性骨关节炎手指关节的数量与SBA之间的关系，并对非侵蚀性骨关节炎手指关节的数量进行了调整。在2236名参与者中，用线性回归的方法探讨了侵蚀性手骨关节炎与股骨颈骨密度之间的关系。分析根据年龄、性别和体重指数进行了调整。手侵蚀性骨性关节炎患者患膝关节SBA的几率增加(OR=1.60，95%CI为1.07~2.38)。当将非侵蚀性骨关节炎关节的数量调整为疾病负担的替代物时，侵蚀性骨关节炎手指关节的数量与SBA之间的关系变得不显著。与无手骨关节炎的受试者相比，侵蚀性手性骨性关节炎患者骨密度升高的趋势不明显。侵袭性手部骨关节炎与膝关节SBA有关，但这种关系可能最好的解释是疾病负担加重。未发现腐蚀性手骨密度与骨密度之间存在显著的相关性。
To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index. Participants with erosive hand OA had increased odds of knee SBA (OR=1.60, 95% CI 1.07 to 2.38). The relation between the number of erosive OA finger joints and SBA became non-significant when adjusted for the number of non-erosive OA joints as a proxy for the burden of disease. There was a non-significant trend towards higher BMD in erosive hand OA compared with participants without hand OA. Erosive hand OA was associated with knee SBA, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand OA with BMD was found.
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影响因子：
27.4
作者：
Bijsterbosch, J.;van Bemmel, J. M.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
DOI：
10.1097/01.gme.0000179048.08371.8e
发表时间：
2006-05-01
影响因子：
2.7
作者：
Zoli, Angelo;Lizzio, Marco M.;Ferraccioli, Glanfranco
通讯作者：
Ferraccioli, Glanfranco
影响因子：
27.4
作者：
Neogi T;Nevitt M;Niu J;Sharma L;Roemer F;Guermazi A;Lewis CE;Torner J;Javaid K;Felson D
通讯作者：
Felson D
影响因子：
27.4
作者：
Haugen IK;Englund M;Aliabadi P;Niu J;Clancy M;Kvien TK;Felson DT
通讯作者：
Felson DT
影响因子：
3.9
作者：
Haugen, Ida K.;Cotofana, Sebastian;Eckstein, Felix
通讯作者：
Eckstein, Felix