From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.
From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world.
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DOI：
10.3748/wjg.v23.i29.5282
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发表时间：
2017-08-07
影响因子：
4.3
通讯作者：
Kouraklis G
中科院分区：
文献类型：
--
作者：
Dimitroulis D;Damaskos C;Valsami S;Davakis S;Garmpis N;Spartalis E;Athanasiou A;Moris D;Sakellariou S;Kykalos S;Tsourouflis G;Garmpi A;Delladetsima I;Kontzoglou K;Kouraklis G
肝细胞癌（Hepatocellular carcinoma，HCC）是西方国家最常见的原发性肝脏恶性肿瘤，也是第三大恶性肿瘤死亡原因。肝细胞癌的明确病因是慢性肝脏感染，如B型肝炎病毒或慢性丙型肝炎病毒，非酒精性脂肪肝，黄曲霉毒素的消耗和吸烟。临床表现差异很大，患者可以是无症状的，而病理学从右上腹象限油漆和体重减轻延伸到阻塞性黄疸和嗜睡。影像学检查是肝癌诊断、治疗和随访的第一关，也是最重要的环节之一。巴塞罗那临床肝癌分期系统仍然是HCC管理指南中使用最广泛的分类系统。到目前为止，HCC仍然是早期诊断和有效治疗的挑战;治疗管理集中在肝切除术，原位肝移植，消融治疗，化疗栓塞和使用细胞毒性药物和靶向药物的全身治疗。本文综述了肝细胞癌的流行病学、病理学、诊断和治疗的最新证据。
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma.
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影响因子：
2.9
作者：
CHUONG, JJH;LIVSTONE, EM;BARWICK, KW
通讯作者：
BARWICK, KW
影响因子：
4.2
作者：
El-Serag, Hashem B.
通讯作者：
El-Serag, Hashem B.
影响因子：
45.3
作者：
Abou-Alfa, Ghassan K.;Schwartz, Lawrence;Saltz, Leonard B.
通讯作者：
Saltz, Leonard B.
影响因子：
8.4
作者：
通讯作者：
--
DOI：
10.5812/iranjradiol.8242
发表时间：
2012-11
期刊：
Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society
影响因子：
--
作者：
Ghanaati H;Alavian SM;Jafarian A;Ebrahimi Daryani N;Nassiri-Toosi M;Jalali AH;Shakiba M
通讯作者：
Shakiba M