The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury.
The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury.
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肠道菌群及其代谢产物在肠道缺血再灌注损伤所致肠道及肠外器官损伤中的作用
DOI：
10.7150/ijbs.71491
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发表时间：
2022
影响因子：
9.2
通讯作者：
Liu, Ke-Xuan
中科院分区：
文献类型：
--
作者：
Deng, Fan;Lin, Ze-Bin;Sun, Qi-Shun;Min, Yue;Zhang, Yue;Chen, Yu;Chen, Wen-Ting;Hu, Jing-Juan;Liu, Ke-Xuan
肠道缺血/再灌注（I/R）是临床重症患者常见的病理生理过程，肠道I/R损伤对患者全身病理生理状态的影响远大于原发性肠道损伤。近年来，越来越多的证据表明肠道菌群及其代谢产物在肠道I/R损伤的发生、发展、诊断和治疗中发挥着重要作用。肠道微生物群受到宿主基因、免疫反应、饮食、药物和其他因素的调节。肠道微生物群的代谢和免疫潜力决定了其对宿主健康和疾病的重要意义。因此，针对肠道微生物群及其代谢物可能是治疗肠道缺血再灌注损伤和肠道缺血再灌注引起的肠外器官损伤的有效疗法。本文重点综述肠道菌群及其代谢产物在肠道I/R损伤和肠道I/R诱发的肠外器官损伤中的作用，并总结调节肠道菌群治疗肠道I/R损伤和肠道I/R诱发的肠外器官损伤的最新进展。
Intestinal ischemia/reperfusion (I/R) is a common pathophysiological process in clinical severe patients, and the effect of intestinal I/R injury on the patient's systemic pathophysiological state is far greater than that of primary intestinal injury. In recent years, more and more evidence has shown that intestinal microbiota and its metabolites play an important role in the occurrence, development, diagnosis and treatment of intestinal I/R injury. Intestinal microbiota is regulated by host genes, immune response, diet, drugs and other factors. The metabolism and immune potential of intestinal microbiota determine its important significance in host health and diseases. Therefore, targeting the intestinal microbiota and its metabolites may be an effective therapy for the treatment of intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury. This review focuses on the role of intestinal microbiota and its metabolites in intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury, and summarizes the latest progress in regulating intestinal microbiota to treat intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury.
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