Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia.
Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia.
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DOI：
10.1080/19490976.2021.2000275
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Chassaing B
中科院分区：
文献类型：
--
作者：
Delaroque C;Chervy M;Gewirtz AT;Chassaing B
一系列慢性炎症性疾病，包括肥胖症和糖尿病等代谢性疾病，被认为是由肠道微生物区系紊乱引起的。这种疾病对低收入社区的影响不成比例，这些社区经常受到长期压力和住房密度增加的困扰。因此，我们假设过度拥挤的住房可能会促进压力、微生物区系失调、炎症，从而导致代谢性疾病。我们在一个易于处理的社交过度拥挤(SOC)小鼠模型中测试了这一假设，在该模型中，小鼠的饲养密度是正常密度的两倍。SOC对一些广泛使用的测试(开场、高架迷宫和明/暗测试)的行为有适度的影响，并导致皮质酮水平急剧上升。这些应激指数与轻度慢性肠道炎症、高血糖、结肠细胞因子升高以及肠道微生物区系组成的改变有关。所有这些SOC的后果都被广谱抗生素消除，而一些(炎症和高血糖)通过微生物区系移植从SOC小鼠传播到正常密度饲养的无菌小鼠。总之，这些结果表明，肠道微生物区系在推动压力、炎症和慢性疾病方面发挥了核心作用，这些疾病是由过度拥挤的住房所促进的。
An array of chronic inflammatory diseases, including metabolic diseases such as obesity and diabetes, are thought to be promoted by disturbance of the intestinal microbiota. Such diseases disproportionately impact low-income communities, which are frequently afflicted by chronic stress and increased density housing. Hence, we hypothesized that overcrowded housing might promote stress, microbiota dysbiosis, inflammation, and, consequently, metabolic diseases. We tested this hypothesis in a tractable murine model of social overcrowding (SOC), in which mice were housed at twice normal density. SOC moderately impacted behavior in some widely used assays (Open Field, Elevated Plus Maze and Light/Dark tests) and resulted in a stark increase in corticosterone levels. Such indices of stress were associated with mild chronic gut inflammation, hyperglycemia, elevations in colonic cytokines, and alterations in gut microbiota composition. All of these consequences of SOC were eliminated by broad spectrum antibiotics, while some (inflammation and hyperglycemia) were transmitted by microbiota transplantation from SOC mice to germfree mice housed at normal density. Altogether, these results suggest a central role for intestinal microbiota in driving stress, inflammation, and chronic diseases that are promoted by overcrowded housing.
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影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Chassaing B;Srinivasan G;Delgado MA;Young AN;Gewirtz AT;Vijay-Kumar M
通讯作者：
Vijay-Kumar M
影响因子：
4.9
作者：
Keubler LM;Buettner M;Häger C;Bleich A
通讯作者：
Bleich A
影响因子：
4.1
作者：
Ferreira CM;Vieira AT;Vinolo MA;Oliveira FA;Curi R;Martins Fdos S
通讯作者：
Martins Fdos S