Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.

Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.
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DOI:
10.1083/jcb.201311051
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发表时间:
2014-03-03
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Parton RG
Parton RG
中科院分区:
其他
文献类型:
--
作者:
Pol A;Gross SP;Parton RG

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脂滴(Lipid droplets,LD)是一种广泛存在于真核细胞和部分原核细胞中的动态细胞器,储存和供应脂质,用于能量代谢、膜合成和产生必需的脂质衍生分子。在过去的十年中,由于LD与流行的人类疾病之间的联系以及LD新的和意想不到的功能的发现,对细胞器细胞生物学的兴趣呈指数级增长。因此,最近在了解LD在哪里以及如何形成以及协调LD生物发生的特定脂质途径方面取得了重大进展。
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and production of essential lipid-derived molecules. Interest in the organelle’s cell biology has exponentially increased over the last decade due to the link between LDs and prevalent human diseases and the discovery of new and unexpected functions of LDs. As a result, there has been significant recent progress toward understanding where and how LDs are formed, and the specific lipid pathways that coordinate LD biogenesis.
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