Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer.
Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer.
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DOI：
10.1155/2012/165879
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发表时间：
2012
影响因子：
4.6
通讯作者：
Kawanishi S
中科院分区：
文献类型：
--
作者：
Thanan R;Murata M;Ma N;Hammam O;Wishahi M;El Leithy T;Hiraku Y;Oikawa S;Kawanishi S
炎症可能通过环氧合酶-2(COX-2)表达介导的前列腺素E2(PGE2)产生激活干细胞。我们用免疫组织化学方法检测了膀胱炎和癌组织中干细胞标志物(Oct3/4和CD44v6)和COX-2的表达。嗜血杆菌相关性膀胱炎和癌组织中Oct3/4的免疫反应性显著高于正常组织。CD44v6在无血瘤链霉菌膀胱癌组织中的表达明显高于正常组织。COX-2定位于癌细胞的胞膜、胞浆和胞核。有趣的是，COX-2的核定位与Oct3/4和CD44v6在感染和不感染嗜血杆菌的膀胱癌组织中的表达显著相关。COX-2激活可能参与了炎症介导的干细胞增殖/分化在膀胱癌发生中的作用。
Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression of stemness markers (Oct3/4 and CD44v6) and COX-2 in urinary bladder tissues obtained from cystitis and cancer patients with and without Schistosoma haematobium infections. Immunoreactivity to Oct3/4 was significantly higher in S. haematobium-associated cystitis and cancer tissues than in normal tissues. CD44v6 expression was significantly higher in bladder cancer without S. haematobium than in normal tissues. COX-2 was located in the cytoplasmic membrane, cytoplasm, and nucleus of the cancer cells. Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without S. haematobium infection, respectively. COX-2 activation may be involved in inflammation-mediated stem cell proliferation/differentiation in urinary bladder carcinogenesis.
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