The Selective Impairment of Resting-State Functional Connectivity of the Lateral Subregion of the Frontal Pole in Schizophrenia
The Selective Impairment of Resting-State Functional Connectivity of the Lateral Subregion of the Frontal Pole in Schizophrenia
复制标题
精神分裂症额极外侧亚区静息态功能连接的选择性损伤
DOI：
10.1371/journal.pone.0119176
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发表时间：
2015-03
期刊：
影响因子：
3.7
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Qin, Wen;Zhu, Jiajia;Zhuo, Chuanjun;Yu, Chunshui
Objective Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC changes of the frontal pole (FP) remain unclear. The FP contains several subregions with different connection patterns; however, it is unknown whether the FP subregions are differentially affected in schizophrenia. To explore this possibility, we compared rsFC differences of the FP subregions between schizophrenia patients and healthy controls. Method One hundred healthy controls and 91 patients with schizophrenia underwent resting-state functional MRI with a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduced susceptibility-induced signal loss and distortion. The FP was subdivided into the orbital (FPo), medial (FPm), and lateral (FPl) subregions. Mean fMRI time series were extracted for each FP subregion and entered into a seed-based rsFC analysis. Results The FP subregions exhibited differential rsFC patterns in both healthy controls and schizophrenia patients. Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/precuneus, temporal cortex and inferior parietal lobule in schizophrenia. Although the FPl exhibited obvious atrophy, rsFC changes were unrelated to volumetric atrophy in the FPl, to duration of illness, and to antipsychotic medication dosage. No significant differences were observed in the rsFCs of other FP subregions. Conclusion These findings suggest a selective (the lateral subregion) functional disconnection of the FP subregions in schizophrenia.
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影响因子：
3.4
作者：
M. Bosia;R. Riccaboni;S. Poletti
通讯作者：
M. Bosia;R. Riccaboni;S. Poletti
影响因子：
10.6
作者：
Jamadar, Sharna;O'Neil, Kasey M.;Pearlson, Godfrey D.;Ansari, Mahvesh;Gill, Adrienne;Jagannathan, Kanchana;Assaf, Michal
通讯作者：
Assaf, Michal
DOI：
10.1016/j.encep.2009.12.011
发表时间：
2010
期刊：
L'Encephale
影响因子：
--
作者：
A. Grosselin;A. Royer;F. Schneider;D. Brouillet;S. Martin;J. Pellet;F. Lang;C. Massoubre
通讯作者：
A. Grosselin;A. Royer;F. Schneider;D. Brouillet;S. Martin;J. Pellet;F. Lang;C. Massoubre
影响因子：
3
作者：
Kim, Dae Il;Sui, Jing;Rachakonda, Srinivas;White, Tonya;Manoach, Dara S.;Clark, V. P.;Ho, Beng Choon;Schulz, S. Charles;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
影响因子：
4.5
作者：
Rosso, Isabelle M.;Makris, Nikos;Thermenos, Heidi W.;Hodge, Steven M.;Brown, Ariel;Kennedy, David;Caviness, Verne S.;Faraone, Stephen V.;Tsuang, Ming T.;Seidman, Larry J.
通讯作者：
Seidman, Larry J.