Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder.
Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder.
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DOI：
10.1016/j.biopsych.2012.07.027
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发表时间：
2013-03-15
影响因子：
10.6
通讯作者：
Assaf, Michal
中科院分区：
文献类型：
--
作者：
Jamadar, Sharna;O'Neil, Kasey M.;Pearlson, Godfrey D.;Ansari, Mahvesh;Gill, Adrienne;Jagannathan, Kanchana;Assaf, Michal
关键词：
The Semantic Object Retrieval Task (SORT) requires participants to indicate whether word pairs recall a third object. Schizophrenia individuals (SZ) tend to report associations between non-associated word pairs; this over-retrieval is related to formal thought disorder (FTD). Since semantic memory impairments and psychosis are not specific to SZ but are also found in bipolar disorder (BP), we examined whether SORT impairments and their relationship to symptoms is also present in BP. Participants (n=239; healthy controls (HC)=133; BP=32; SZ=74) completed SORT while undergoing fMRI scanning. Retrieval accuracy negatively correlated with negative symptoms and No-Retrieval accuracy negatively correlated with FTD severity in SZ but not BP. Retrieval vs. No-Retrieval trials activated a distributed fronto-parieto-temporal network; bilateral inferior parietal lobule (IPL) activity was larger in HC vs. SZ and HC vs. BP, with no difference in SZ vs. BP. Right IPL activity positively correlated with positive and general psychosis symptoms in SZ but not BP. SZ reported more associations between unrelated word pairs than HC; this over- retrieval increased with FTD severity. SZ were also more likely to fail to find associations between related word pairs; this under-retrieval increased with negative symptom severity. fMRI-symptom correlations in IPL in SZ are consistent with arguments that IPL abnormality relates to loosening of associations in SZ. By comparison, BP showed intermediate impairments on SORT, uncorrelated with symptoms, suggesting that the relationship between SORT performance, fMRI activity and psychotic symptoms is schizophrenia-specific.
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影响因子：
5.7
作者：
Binder JR;Gross WL;Allendorfer JB;Bonilha L;Chapin J;Edwards JC;Grabowski TJ;Langfitt JT;Loring DW;Lowe MJ;Koenig K;Morgan PS;Ojemann JG;Rorden C;Szaflarski JP;Tivarus ME;Weaver KE
通讯作者：
Weaver KE
影响因子：
12.3
作者：
Carroll LS;Owen MJ
通讯作者：
Owen MJ
影响因子：
5.4
作者：
Goes, Fernando S.;Sadler, Bradley;Potash, James B.
通讯作者：
Potash, James B.
影响因子：
2.3
作者：
Brown, Gregory G.;Lee, Jun-Seok;Strigo, Irina A.;Caligiuri, Michael P.;Meloy, M. J.;Lohr, James
通讯作者：
Lohr, James
影响因子：
10.6
作者：
Assaf, M;Rivkin, PR;Pearlson, GD
通讯作者：
Pearlson, GD