Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo.
Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo.
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DOI：
10.1111/exd.12449
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发表时间：
2014-08
影响因子：
3.6
通讯作者：
Le Poole IC
中科院分区：
文献类型：
--
作者：
Webb KC;Eby JM;Hariharan V;Hernandez C;Luiten RM;Le Poole IC
Depigmentation in vitiligo occurs by progressive loss of melanocytes from the basal layer of the skin, and can be psychologically devastating to patients. T cell-mediated autoimmunity explains the progressive nature of this disease. Rather than being confronted with periods of rapid depigmentation and bouts of repigmentation, patients with long-standing, treatment-resistant vitiligo can undergo depigmentation treatment. The objective is to remove residual pigmentation in order to achieve a cosmetically acceptable result- that of skin with a uniform appearance. In the USA, only the use of mono-benzyl ether of hydroquinone (MBEH) is approved for this purpose. However, satisfactory results can take time to appear, and there is a risk of repigmentation. MBEH induces necrotic melanocyte death followed by a cytotoxic T cell response to remaining, distant melanocytes. As cytotoxic T cell responses are instrumental to depigmentation, we propose that combining MBEH with immune adjuvant therapies will accelerate immune-mediated melanocyte destruction to achieve faster, more definitive depigmentation than with MBEH alone. Since Toll-like Receptor (TLR) agonists-imiquimod, CpG, and Heat Shock Protein 70 (HSP 70)-all support powerful Th1 responses, we propose that using MBEH in combination with these agents can achieve superior depigmentation results for vitiligo patients.
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影响因子：
--
作者：
Bubacco, L;Vijgenboom, E;Canters, GW
通讯作者：
Canters, GW
DOI：
10.4103/0378-6323.90946
发表时间：
2012-01-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
6.1
作者：
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通讯作者：
MARSHALL, MR
影响因子：
6.5
作者：
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通讯作者：
Le Poole, I. Caroline
影响因子：
4.1
作者：
Aydogan, K;Turan, OF;Tunali, S
通讯作者：
Tunali, S