Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trial.
Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trial.
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DOI：
10.1186/1745-6215-12-47
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发表时间：
2011-02-17
期刊：
影响因子：
2.5
通讯作者：
Almeida OP
中科院分区：
文献类型：
--
作者：
Vidovich MR;Shaw J;Flicker L;Almeida OP
参与认知刺激疗法（CST）可能会降低阿尔茨海默病（AD）患者认知能力下降的速度，但目前尚不清楚护理人员提供活动的培训是否足以改善患者的临床结果。通过针对阿尔茨海默病的认知运动促进健康老龄化 (PACE-AD) 研究旨在确定，当干预措施仅提供给护理人员而不是护理人员和患者时，是否可以通过参与认知刺激活动来实现六个月内认知功能的改变。该研究旨在根据 NINCDS-ADRDS 标准招募 128 名可能患有 AD 的社区居民男性和女性。参与者将被随机分配到两个认知活动治疗组之一：(1) 患有轻度 AD 的参与者及其同伴 (2) 单独患有轻度 AD 的参与者的同伴。干预措施将包括为期十二周的认知刺激计划。该计划的七周将包括每周一次的 90 分钟小组会议，而该计划的其余几周将包括有电话支持的结构化家庭活动。该研究的主要结果指标是阿尔茨海默病认知评估量表 (ADAS-COG) 总分较基线的变化。次要结果包括轻度 AD 参与者的健康相关生活质量、情绪、记忆、语言、执行功能、独立生活能力和精神症状的变化。同伴的生活质量、情绪和总体健康状况的变化也将受到监测。主要终点将在基线评估后 13 周和 26 周收集。拟议的项目将提供证据证明 CST 对 AD 患者及其同伴是否比单独用于同伴更有益。寻求的结果包括减少患有轻度 AD 的老年人的认知能力进一步下降并提高生活质量。我们预计这项研究的结果将对开发具有成本效益的循证最佳实践来治疗轻度 AD 患者产生影响。 ACTRN12610000653066
Participation in cognitive stimulation therapy (CST) may reduce the rate of cognitive decline in people with Alzheimer's disease (AD), however it is unclear if the training of carers to deliver activities is sufficient to improve the clinical outcome of patients. The Promoting Healthy Ageing with Cognitive Exercise for Alzheimer's Disease (PACE-AD) study has been designed to determine if change in cognitive function over a six month period can be achieved with participation in cognitive stimulating activities when the intervention is delivered to carers only as opposed to carers and patients. The study will aim to recruit 128 community-dwelling men and women with probable AD according to NINCDS-ADRDS criteria. Participants will be randomly allocated to one of two cognitive activity treatment groups: (1) Participants with mild AD and their companions together (2) Companions of participants with mild AD alone. The intervention will consist of a twelve-week program of cognitive stimulation. Seven weeks of the program will involve 90-minute group sessions delivered once per week while the remaining weeks of the program will involve structured home based activities with telephone support. The primary outcome measure of the study is the change from baseline in the total score on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-COG). Secondary outcomes of interest include changes in health related quality of life, mood, memory, language, executive functions, independent living abilities and psychiatric symptoms for participants with mild AD. Changes in companion quality of life, mood, and general health will also be monitored. Primary endpoints will be collected 13 and 26 weeks after the baseline assessment. The proposed project will provide evidence as to whether CST for people with AD and their companions is more beneficial than when used for companions alone. Outcomes sought include a reduction of further cognitive decline and improved quality of life amongst older adults with mild AD. We anticipate that the results of this study will have implications for the development of cost-effective evidence-based best practice to treat people with mild AD. ACTRN12610000653066
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10.5
作者：
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通讯作者：
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