Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area.
Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area.
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BDNF Val66Met 多态性对长寿地区普通人群代谢风险的潜在不利影响
DOI：
10.1186/s12877-016-0393-0
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发表时间：
2017-01-05
期刊：
影响因子：
4.1
通讯作者：
Yin RX
中科院分区：
文献类型：
--
作者：
Peng JH;Liu CW;Pan SL;Wu HY;Liang QH;Gan RJ;Huang L;Ding Y;Bian ZY;Huang H;Lv ZP;Zhou XL;Yin RX
BackgroundBrain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi.MethodsBDNF Val66Met was typed by ARMS-PCR for 487 Zhuang long-lived individuals (age ≥ 90, long-lived group,LG), 593 of their offspring (age 60–77, offspring group,OG) and 582 ethnic-matched healthy controls (aged 60–75, control group,CG) from Hongshui River Basin. The correlations of genotypes with metabolic risks were then determined.ResultsAs a result, no statistical difference was observed on the distribution of allelic and genotypic frequencies of BDNF Val66Met among the three groups (allP> 0.05) except that AA genotype was dramatically higher in females than in males of CG. The HDL-C level of A allele (GA/AA genotype) carriers was profoundly lower than was non-A (GG genotype) carriers in the total population and the CG (P =0.009 and 0.006, respectively), which maintained in females, hyperglycemic and normolipidemic subgroup of CG after stratification by gender, BMI, glucose and lipid status. Furthermore, allele A carriers, with a higher systolic blood pressure, exhibited 1.63 folds higher risk than non-A carriers to be overweight in CG (OR= 1.63, 95%CI: 1.05 - 2.55, P = 0.012). Multiple regression analysis displayed that the TC level of LG reversely associated with BDNF Val66Met genotype.ConclusionsThese data suggested that BDNF 66Met may play unfavorable roles in blood pressure and lipid profiles in the general population in Hongshui River area which might in part underscore their poorer survivorship versus the successful aging individuals and their offspring.
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影响因子：
6.9
作者：
Hong, Kyung-Won;Lim, Ji-Eun;Oh, Bermseok
通讯作者：
Oh, Bermseok
影响因子：
5.4
作者：
Bonaccorso, Stefania;Sodhi, Monsheel;Meltzer, Herbert Y.
通讯作者：
Meltzer, Herbert Y.
影响因子：
8.2
作者：
Krabbe, K. S.;Nielsen, A. R.;Pedersen, B. K.
通讯作者：
Pedersen, B. K.
DOI：
10.1111/j.1532-5415.2009.02345.x
发表时间：
2009-08-01
影响因子：
6.3
作者：
Krabbe, Karen S.;Mortensen, Erik L.;Bruunsgaard, Helle
通讯作者：
Bruunsgaard, Helle
影响因子：
3.3
作者：
Ma XY;Qiu WQ;Smith CE;Parnell LD;Jiang ZY;Ordovas JM;Tucker KL;Lai CQ
通讯作者：
Lai CQ