Acellular mineralized allogenic block bone graft does not remodel during the 10 weeks following concurrent implant placement in a rabbit femoral model.
Acellular mineralized allogenic block bone graft does not remodel during the 10 weeks following concurrent implant placement in a rabbit femoral model.
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DOI：
10.1111/clr.13544
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发表时间：
2020-01
影响因子：
4.3
通讯作者：
Schwartz Z
中科院分区：
文献类型：
--
作者：
Cohen DJ;Scott KM;Kulkarni AN;Wayne JS;Boyan BD;Schwartz Z
由于骨丢失，骨内植入物通常需要添加骨移植物以支持充分的初次固定、骨再生和骨整合。本研究的目的是比较在同时插入种植体期间使用自体和同种异体骨移植物的有效性。将直径为4 mm的兔骨干自体骨移植物或同种异体骨移植物（n=16/组）植入3.5kg雄性新西兰白色兔股骨近端的4 mm缺损中，中心预钻孔为3.2mm。放置机加工的3.2× 10 mm喷砂、酸蚀刻钛铝钒（Ti6 Al 4V）种植体。将对照植入物放置在对侧肢体中逐渐钻取的3.2mm孔中。插入后第70天，通过microCT和钙化组织学或通过机械扭矩和推出测试以及脱钙组织学分析样本。两种移植物均与自体骨结合。MicroCT显示同种异体骨移植组的骨体积（BV）和骨体积/总体积（BV/TV）较小，但组织学显示组间BV或BV/TV无差异。同种异体移植物缺乏活细胞，而自体移植物细胞化。两组之间的最大旋出扭矩无差异。与自体移植物组相比，同种异体移植物-骨界面处的压缩载荷显著较低。与自体移植物相比，同种异体移植物组中与植入物接触的骨更少，最大压缩载荷显著更小。空骨陷窝表明同种异体骨保持无细胞状态。总之，与自体移植物相比，与植入物同时植入的同种异体骨块产生的骨质量较差。
Due to bone loss, endosseous implants often require addition of a bone graft to support adequate primary fixation, bone regeneration, and osseointegration. The aim of this study was to compare effectiveness of autogeneic and allogeneic bone grafts when used during simultaneous insertion of the implant. 4mm diameter rabbit diaphyseal bone autografts or allografts (n=16/group) with a 3.2mm pre-drilled hole in the center were placed into a 4mm defect in the proximal femur of 3.5kg male New Zealand White rabbits. Machined 3.2×10mm grit blasted, acid-etched titanium-aluminum-vanadium (Ti6Al4V) implants were placed. Control implants were placed into progressively drilled 3.2mm holes in the contralateral limbs. Post-insertion day 70, samples were analyzed by microCT and calcified histology, or by mechanical torque and push-out testing followed by decalcified histology. Both grafts were integrated with the native bone. MicroCT showed less bone volume (BV) and bone volume/total volume (BV/TV) in the allograft group, but histology showed no differences in BV or BV/TV between groups. Allograft lacked living cells whereas autograft was cellularized. No difference was found in maximum removal torque between groups. Compressive loading at the graft-to-bone interface was significantly lower in allograft compared to autograft groups. There was less bone in contact with the implant, and significantly less maximum compressive load in the allograft group compared to autograft. The allograft remained acellular as demonstrated by empty lacunae. Taken together, block allograft implanted simultaneously with an implant produces a poorer quality bone compared to autograft.
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DOI：
10.1016/j.jmbbm.2012.08.001
发表时间：
2013-01-01
影响因子：
3.9
作者：
Felfel, R. M.;Ahmed, I.;Rudd, C. D.
通讯作者：
Rudd, C. D.
影响因子：
2.2
作者：
Heinemann, Friedhelm;Hasan, Istabrak;Mundt, Torsten
通讯作者：
Mundt, Torsten
影响因子：
1.3
作者：
Hollawell, Shane M.
通讯作者：
Hollawell, Shane M.
影响因子：
1.9
作者：
Al-Abedalla, Khadijeh;Torres, Jesus;Tamimi, Faleh
通讯作者：
Tamimi, Faleh
影响因子：
--
作者：
Petrungaro, Paul S;Amar, Salomon
通讯作者：
Amar, Salomon