Understanding and engineering RNA sequence specificity of PUF proteins.
Understanding and engineering RNA sequence specificity of PUF proteins.
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DOI:
10.1016/j.sbi.2008.12.009
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发表时间:
2009-02
影响因子:
6.8
通讯作者:
Hall, Traci M. Tanaka
中科院分区:
文献类型:
--
作者:
Lu, Gang;Dolgner, Stephen J.;Hall, Traci M. Tanaka
PUF proteins are RNA-binding proteins named for founding members PUMILIO and FBF. Together these proteins represent the range of known RNA recognition properties. PUMILIO is a prototypical PUF protein whose RNA sequence specificity is simple, elegant, and predictable. FBF displays differences in RNA recognition that represent divergence from the prototype. Here we review recent studies that examine the engineering of sequence specificity of PUF proteins and its applications as well as studies that increase our understanding of the natural diversity of RNA recognition by this family of proteins.
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