Selective anoxic injury to thick ascending limb: an anginal syndrome of the renal medulla?
Selective anoxic injury to thick ascending limb: an anginal syndrome of the renal medulla?
复制标题
粗升肢选择性缺氧损伤：肾髓质心绞痛综合征？
DOI：
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发表时间：
1984
影响因子：
--
通讯作者：
F. Epstein
中科院分区：
文献类型：
--
作者：
M. Brezis;S. Rosen;P. Silva;F. Epstein
人们对肾实质内 O2 可用性的皮质髓质梯度的认识已有一段时间了，但对其病理生理学意义的认识尚不明确。在用无细胞白蛋白-林格氏培养基对大鼠肾脏进行分离灌注期间，持续观察到特定的解剖学病变，局限于髓质厚的亨利氏袢升肢（mTAL），从线粒体肿胀到核固缩和完全细胞破坏，该病变进展超过 90 分钟。缺氧会加剧病变，并通过增加灌注的氧含量或减少 mTAL 细胞的运输工作来改善。由于其解剖位置与髓质血管系统造成的低氧气供应及其高电解质输送率相关，mTAL 似乎对缺氧极为敏感。由氧气供需失衡引起的缺氧病变可能对理解缺血性肾损伤具有重要意义。
Cortico-medullary gradients of O2 availability within the renal parenchyma have been appreciated for some time, but not their pathophysiological significance. During isolated perfusion of the rat kidney with cell-free albumin-Ringer's medium, a specific anatomical lesion is consistently observed, confined to the medullary thick ascending limb of Henle's loop (mTAL), that progresses over 90 min from mitochondrial swelling to nuclear pyknosis and complete cellular disruption. The lesion is exaggerated by oxygen deprivation and ameliorated by increasing the oxygen content of the perfusion or by reducing the transport work of mTAL cells. Because of its anatomical location associated with a low O2 supply imposed by the medullary vascular system and its high rate of electrolyte transport, the mTAL appears to be exquisitely sensitive to O2 deprivation. The consequent anoxic lesion, resulting from an imbalance between O2 supply and demand, may have important implications for the understanding of ischemic renal injury.
选择性谷胱甘肽消耗对离体灌注大鼠肾脏功能和结构的影响。
影响因子：
19.6
作者：
Brezis,M;Rosen,S;Silva,P;Epstein,FH
通讯作者：
Epstein,FH