Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions.
Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions.
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DOI：
10.1007/s10753-014-9914-1
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发表时间：
2014-08
期刊：
影响因子：
5.1
通讯作者：
Arsenescu, Violeta
中科院分区：
文献类型：
--
作者：
Ghigliotti, Giorgio;Barisione, Chiara;Garibaldi, Silvano;Fabbi, Patrizia;Brunelli, Claudio;Spallarossa, Paolo;Altieri, Paola;Rosa, Gianmarco;Spinella, Giovanni;Palombo, Domenico;Arsenescu, Razvan;Arsenescu, Violeta
关键词：
脂肪组织炎症介导体脂肪过度积累与几种慢性炎症性疾病之间的关联。肥胖相关脂肪组织炎症的高患病率不仅见于心血管疾病患者，也见于炎症性肠病、腹主动脉瘤或心肾综合征患者。除了过量的热量摄入，其他触发因素促进内脏脂肪组织炎症，随后是慢性、低度的全身炎症。免疫细胞在炎症和肥大脂肪组织中的浸润和积聚促进炎症细胞因子的产生，导致靶器官损伤。这种合并症似乎将全身性脂肪组织炎症和更严重的慢性炎症性疾病的个体划分为亚群，这些疾病对常规治疗是难治性的。这篇综述强调了脂肪组织免疫反应与内脏脂肪相关慢性炎症疾病的病理生理学之间的联系，同时提出了一些新的治疗策略。
Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular conditions but also in patients with inflammatory bowel diseases, abdominal aortic aneurysm, or cardiorenal syndrome. In addition to excessive caloric intake, other triggers promote visceral adipose tissue inflammation followed by chronic, low-grade systemic inflammation. The infiltration and accumulation of immune cells in the inflamed and hypertrophied adipose tissue promote the production of inflammatory cytokines, contributing to target organ damages. This comorbidity seems to delimit subgroups of individuals with systemic adipose tissue inflammation and more severe chronic inflammatory diseases that are refractory to conventional treatment. This review highlights the association between adipose tissue immune response and the pathophysiology of visceral adiposity-related chronic inflammatory diseases, while suggesting several new therapeutic strategies.
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