A three-compartment non-linear model of myocardial cell conduction block during photosensitization
A three-compartment non-linear model of myocardial cell conduction block during photosensitization
复制标题
光敏过程中心肌细胞传导阻滞的三室非线性模型
DOI：
10.1007/s11517-021-02329-7
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发表时间：
2021
影响因子：
3.2
通讯作者：
Emiyu Ogawa,Eitaro Aiyoshi,Tsunenori Arai
中科院分区：
文献类型：
--
作者：
星野 秀晃;盛田 健人;武田 大介;長谷川 巧実;若林 哲史;Emiyu Ogawa,Eitaro Aiyoshi,Tsunenori Arai
本研究构建了一个新的光敏化反应过程中心肌电传导阻滞的非线性模型，以识别易受伤害的细胞群，并生成快速心律失常导管消融后复发风险的指数。提出了一个由导电细胞、脆弱细胞和阻塞细胞组成的三室模型。为了确定从脆弱细胞到导电细胞转变的速率参数的非线性，我们将以前报道的一个非线性模型和我们新提出的模型与光敏反应过程中心肌细胞电传导阻滞的非线性速率参数进行了比较。在心肌细胞导线的光敏反应过程中，利用测量的同步性数据，通过双嵌套结构优化了速率参数。与传统模型相比，新模型对实测数据的拟合度更高。当测量值大于0.6时，传统模型的误差之和为0.22，而新模型的误差之和为0.07。从脆弱细胞到导电细胞隔间的非线性速率参数可能是光敏化反应诱导的导电阻断模型的首选结构。该仿真模型为评价光敏化快速性心律失常导管消融术后复发风险提供了一个指标。光敏作用下心肌细胞传导阻滞的三室非线性模型
This study constructed a new non-linear model of myocardial electrical conduction block during photosensitization reaction to identify the vulnerable cell population and generate an index for recurrent risk following catheter ablation for tachyarrhythmia. A three-compartment model of conductive, vulnerable, and blocked cells was proposed. To determine the non-linearity of the rate parameter for the change from vulnerable cells to conductive cells, we compared a previously reported non-linear model and our newly proposed model with non-linear rate parameters in the modeling of myocardial cell electrical conduction block during photosensitization reaction. The rate parameters were optimized via a bi-nested structure using measured synchronicity data during the photosensitization reaction of myocardial cell wires. The newly proposed model had a better fit to the measured data than the conventional model. The sum of the error until the time where the measured value was higher than 0.6, was 0.22 in the conventional model and 0.07 in our new model. The non-linear rate parameter from the vulnerable cell to the conductive cell compartment may be the preferred structure of the electrical conduction block model induced by photosensitization reaction. This simulation model provides an index to evaluate recurrent risk after tachyarrhythmia catheter ablation by photosensitization reaction.Graphical abstractA three-compartment non-linear model of myocardial cell conduction block during photosensitization
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影响因子：
3.8
作者：
O'Neill, David P.;Peng, Tingying;Payne, Stephen J.
通讯作者：
Payne, Stephen J.
DOI：
10.1016/j.physrep.2014.05.002
发表时间：
2014-10-10
期刊：
Physics reports
影响因子：
--
作者：
Qu Z;Hu G;Garfinkel A;Weiss JN
通讯作者：
Weiss JN
影响因子：
2.9
作者：
Weinberg，S. H.
通讯作者：
Weinberg，S. H.
影响因子：
3.3
作者：
E. Ogawa;M. Kurotsu;T. Arai
通讯作者：
T. Arai
影响因子：
4
作者：
Kappadan, Vineesh;Telele, Saba;Christoph, Jan
通讯作者：
Christoph, Jan