In the Wnt of Paneth Cells: Immune-Epithelial Crosstalk in Small Intestinal Crohn's Disease.
In the Wnt of Paneth Cells: Immune-Epithelial Crosstalk in Small Intestinal Crohn's Disease.
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DOI：
10.3389/fimmu.2017.01204
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发表时间：
2017
影响因子：
7.3
通讯作者：
Wehkamp J
中科院分区：
文献类型：
--
作者：
Armbruster NS;Stange EF;Wehkamp J
潘氏细胞是小肠的特化分泌上皮细胞，通过产生抗微生物肽，特别是（但不仅仅是）人α-防御素5（HD 5）和HD 6，在宿主防御和微生物群调节中发挥关键作用。在作为炎性肠病实体的小肠克罗恩病（CD）中，HD 5和HD 6的表达特异性受损，导致屏障紊乱和微生物群落的变化。与小肠CD相关的不同遗传驱动的以及非遗传缺陷影响不同的抗微生物潘氏细胞功能。本文就潘氏细胞与骨髓源性细胞的相互作用机制及Wnt信号通路在回肠CD发病中的作用进行综述。总之，由我们领导的不同研究路线以及现在许多其他小组支持并再次确认了将这种疾病实体分类为潘氏病的建议。
Paneth cells, specialized secretory epithelial cells of the small intestine, play a pivotal role in host defense and regulation of microbiota by producing antimicrobial peptides especially—but not only—the human α-defensin 5 (HD5) and HD6. In small intestinal Crohn’s disease (CD) which is an entity of inflammatory bowel diseases, the expression of HD5 and HD6 is specifically compromised leading to a disturbed barrier and change in the microbial community. Different genetically driven but also non-genetic defects associated with small intestinal CD affect different lines of antimicrobial Paneth cell functions. In this review, we focus on the mechanisms and the crosstalk of Paneth cells and bone marrow-derived cells and highlight recent studies about the role of the Wnt signaling pathway in this connection of ileal CD. In summary, different lines of investigations led by us but also now numerous other groups support and reconfirm the proposed classification of this disease entity as Paneth’s disease.
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