The diversity of antimicrobial resistance is different in Salmonella Typhimurium DT104 from co-located animals and humans
The diversity of antimicrobial resistance is different in Salmonella Typhimurium DT104 from co-located animals and humans
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鼠伤寒沙门氏菌 DT104 的抗菌药物耐药性多样性与同处动物和人类不同
DOI：
10.1098/rspb.2012.0614
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Mather A
中科院分区：
文献类型：
--
作者：
Mather A
在我们的论文中，我们使用苏格兰现有的广泛的鼠伤寒沙门氏菌DT 104数据集，研究了动物和人类的抗菌素耐药性模式。我们得出结论，基于各种新的和统计学上稳健的分析，苏格兰动物种群不太可能是人类DT 104耐药多样性的主要来源。我们远没有得出结论，动物和人类中的抗菌素耐药性沙门氏菌之间没有关联，而是使用新的分析工具和技术来剖析这种关联的性质，这些工具和技术应用于现有的最大数据集之一。我们总结了Collignon教授对我们论文的批评如下：（i）大多数分离株具有动物和人类共同的耐药性特征;（ii）我们过度强调了罕见特征的重要性;（iii）我们忽略了进口食品的问题;（iv）我们研究中被动采样的动物分离株在某种程度上存在偏见。鉴于S.鼠伤寒沙门氏菌DT 104，大多数分离株表现出相同的表型耐药谱并不奇怪。这很可能表明动物和人类分离株之间存在关联，但单凭对这一观察结果的客观解释，无法得出结论，认为这是两个人群之间传播方向上的优势。第二，Collignon教授认为，最重要的是，他指出，我们选择性地给予罕见特征与更常见特征相似的权重。事实并非如此。我们检查了在这两个种群中发现的抗性谱的多样性，通过一系列生态多样性措施，包括从相等贡献到无贡献的稀有谱的所有可能权重（我们原始论文中的图2c，d）。对于所有这些可能的权重，在人类群体中发现的表型比在动物群体中发现的表型更多样化。第三，我们重申了在苏格兰消费的食品（其中大部分是进口的）和我们研究的重点之间的重要区别-当地的动物种群，可能包括沙门氏菌水库，其中我们的样本更具代表性。我们参考的先前关于DT 104的研究并没有证明DT 104主要是通过食物从食用动物传播给人类的;这些研究中的许多
In our paper, we set out to examine antimicrobial resistance patterns in animals and humans, using an existing extensive dataset of Salmonella Typhimurium DT104 in Scotland. We concluded, based on a variety of novel and statistically robust analyses, that the Scottish animal population was unlikely to be the major source of resistance diversity for DT104 in humans. Far from concluding that there was no association between antimicrobial-resistant Salmonella in animals and humans, we set out to dissect the nature of this association using new analytical tools and techniques applied to one of the largest datasets available. We summarize Professor Collignon’s criticisms of our paper as follows:(i) most isolates had a resistance profile that was common to both animals and humans;(ii) we over-emphasized the importance of rare profiles;(iii) we ignored the issue of imported food; and (iv) the passively sampled animal isolates in our study were biased in some way. Given the clonal nature of S. Typhimurium DT104, it is unsurprising that the majority of isolates exhibit the same phenotypic resistance profiles. This may well indicate an association between isolates from animals and humans, but no objective interpretation of this observation alone would conclude that it is informative of any predominance in the direction of transmission between the two populations.Second, and in Professor Collignon’s view, most importantly, he states that we have selectively given similar weights to rare profiles as to more common profiles. This is not the case. We examined the diversity of resistance profiles found in these two populations across a spectrum of ecological diversity measures that include all possible weightings of rare profiles from equal contribution to no contribution (fig. 2c, d in our original paper). For all of these possible weightings, the phenotypes found in the human population are more diverse than those found in the animal population. Third, we reiterate the important distinction between the food products consumed in Scotland (much of which is imported), and the focus of our study—the local animal population that might comprise the Salmonella reservoir, and of which our sample is much more representative. The previous research on DT104 we reference does not demonstrate that DT104 is predominantly spread from food animals to humans via food; many of these studies
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无症状肠沙门氏菌血清型鼠伤寒 DT104 的基因型多样性和抗菌药物耐药性。
DOI：
10.1016/j.meegid.2006.09.003
发表时间：
2007
期刊：
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子：
--
作者：
G. Perron;S. Quessy;A. Letellier;G. Bell
通讯作者：
G. Bell
影响因子：
120.7
作者：
Cody, SH;Abbott, SL;Vugia, DJ
通讯作者：
Vugia, DJ
多重耐药鼠伤寒沙门氏菌 DT104
DOI：
10.2807/esw.02.31.01180-en
发表时间：
1998
期刊：
The New England journal of medicine
影响因子：
--
作者：
C. Akehurst
通讯作者：
C. Akehurst
影响因子：
4.4
作者：
Sharma, Ranjana;Munns, Krysty;McAllister, Tim
通讯作者：
McAllister, Tim
影响因子：
3.3
作者：
DeFrancesco, KA;Cobbold, RN;Hancock, DD
通讯作者：
Hancock, DD