Gene Expression and Functional Changes After Acute Ischemia: Age-Related Differences in Outcome and Mechanisms
Gene Expression and Functional Changes After Acute Ischemia: Age-Related Differences in Outcome and Mechanisms
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急性缺血后基因表达和功能变化：结果和机制的年龄相关差异
DOI：
10.1007/978-3-642-78151-3_31
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发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
R. Floyd
中科院分区：
文献类型：
--
作者：
J. Carney;M. Kindy;Charles D. Smith;K. Wood;T. Tatsuno;Ji Wu;W. Landrum;R. Floyd
脑缺血再灌注损伤是许多临床疾病的常见过程。这些情况包括中风、脑震荡和蛛网膜下腔出血。缺血后损伤的最终过程仍有待描述。已经提出了几种可能的机制。在再灌注损伤过程的早期，已经证明脑中产生的自由基的量显著增加[2，3，11]。自由基损伤的后果之一是脂质和蛋白质氧化[4，12，14]。最近的研究表明，这种配体通道可以被氧化修饰。参与缺血后脑损伤的最可能的配体门控通道候选系统之一是谷氨酸受体激活通道的N-甲基-D-天冬氨酸（NMDA）受体亚型。已证明刺激该受体可增加通过NMDA调节通道和其他钙通道的钙内流[1，8，17]。细胞内游离钙突然增加的后果之一是激活脂肪酶和蛋白酶[1，2，36]。通过不同的药物阻断配体调节和电压敏感性钙通道可预防缺血/再灌注损伤[1，2，17]。在再灌注过程的早期，立即早期基因（IEG）的表达显著增加。在缺血再灌注损伤后表达的IEG中，hsp、c-fos和c-jun已被证明增加。
Ischemia reperfusion injury to brain is a common process in a number of clinical conditions. Among these conditions are stroke, concussion, and subarachnoid hemorrhage. The ultimate process of postischemic injury remains to be described. Several possible mechanisms have been proposed. Early in the process of reperfusion injury it has been demonstrated tat there is a significant increase in the amount of free radicals generated in the brain [2, 3, 11]. One of the consequences of radical damage is lipid and protein oxidation [4, 12, 14]. Recent studies have demonstrated that this ligandgated channel can be oxidatively modified. One of the most likely ligandgated channel candidate systems for its involvement in postischemic brain damage is the N-methyl-D-aspartate (NMDA) receptor subtype of the glutamate receptor activated channel. Stimulation of this receptor has been demonstrated to increase the influx of calcium through the NMDA-regulated channel and via other calcium channels [1, 8, 17]. One of the consequences of the sudden increase in intracellular free calcium is the activation of lipases and proteases [1, 2, 36]. Blockade of ligand–regulated and voltage-sensitive calcium channels by different pharmacologic agents prevents ischemia/reperfusion injury [1, 2, 17]. Early in the reperfusion process there is a significant increase in the expression of immediate early genes (IEGs). Among the IEGs expressed, hsp, c-fos and c-jun have been demonstrated to increase following ischemia reperfusion injury.
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影响因子：
4.1
作者：
KONTOS, HA;WEI, EP
通讯作者：
WEI, EP
小鼠鸟氨酸脱羧酶基因的核苷酸序列。
影响因子：
14.9
作者：
Coffino,P;Chen,EL
通讯作者：
Chen,EL
DOI：
10.1073/pnas.88.23.10540
发表时间：
1991-12-01
影响因子：
11.1
作者：
SMITH, CD;CARNEY, JM;MARKESBERY, WR
通讯作者：
MARKESBERY, WR
影响因子：
56.9
作者：
RAUSCHER, FJ;COHEN, DR;FRANZA, BR
通讯作者：
FRANZA, BR
DOI：
10.1073/pnas.87.13.5144
发表时间：
1990-07-01
影响因子：
11.1
作者：
OLIVER, CN;STARKEREED, PE;FLOYD, RA
通讯作者：
FLOYD, RA