Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts.
Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts.
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类风湿关节炎中滑膜细胞。滑膜成纤维细胞。
DOI：
10.1186/ar2337
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发表时间：
2007
影响因子：
4.9
通讯作者：
Pap, Thomas
中科院分区：
文献类型：
--
作者：
Mueller-Ladner, Ulf;Ospelt, Caroline;Gay, Steffen;Distler, Oliver;Pap, Thomas
一段时间以来，滑膜成纤维细胞被简单地认为是无辜的滑膜细胞，主要负责滑膜内稳态。然而，在过去的十年中，积累了大量证据，表明类风湿性关节炎滑膜成纤维细胞（RASF）是类风湿性关节炎关节破坏的积极驱动因素。已经分析了导致RASF长期激活和合成促炎分子和基质降解酶的细胞内信号级联的细节。分子、细胞和动物研究已经确定了与其他滑膜和炎性细胞的各种相互作用。这种对RASFs在类风湿性关节炎病理生理学中发挥的独特作用的扩展知识已经将这些迷人的细胞推向了前台，并且正在进行确定靶向治疗以抑制其关节破坏潜力的工作。
For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustrating that rheumatoid arthritis synovial fibroblasts (RASFs) are active drivers of joint destruction in rheumatoid arthritis. Details regarding the intracellular signalling cascades that result in long-term activation and synthesis of proinflammatory molecules and matrix-degrading enzymes by RASFs have been analyzed. Molecular, cellular and animal studies have identified various interactions with other synovial and inflammatory cells. This expanded knowledge of the distinct role played by RASFs in the pathophysiology of rheumatoid arthritis has moved these fascinating cells to the fore, and work to identify targeted therapies to inhibit their joint destructive potential is underway.
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