Evolution and diversification of the nuclear envelope.
Evolution and diversification of the nuclear envelope.
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DOI：
10.1080/19491034.2021.1874135
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Field MC
中科院分区：
文献类型：
--
作者：
Padilla-Mejia NE;Makarov AA;Barlow LD;Butterfield ER;Field MC
真核细胞出现在约15亿年前，内膜系统是一个中心特征，促进了细胞内区室的进化。内膜包括核被膜（NE），其将细胞质和核质分开。NE具有普遍的特征：双层脂质膜，核孔复合物（NPC），并与内质网的连续性，表明共同的进化起源。然而，谱系之间的专业化水平仍然不清楚，尽管不同的机制支撑着各种核活动。几种不同的分子进化模式促进细胞器多样化，并了解适用于NE，我们利用模型系统的纯化核膜的蛋白质组数据集进行比较分析。我们发现在广泛保守的蛋白质中核心核功能的富集比谱系特异性队列少，但在核心核功能中富集。这一点，再加上考虑额外的证据，表明，尽管有一个共同的起源，NE已演变为一个高度多样化的细胞器具有显着的血统特异性功能。
Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. The NE possesses universal features: a double lipid bilayer membrane, nuclear pore complexes (NPCs), and continuity with the endoplasmic reticulum, indicating common evolutionary origin. However, levels of specialization between lineages remains unclear, despite distinct mechanisms underpinning various nuclear activities. Several distinct modes of molecular evolution facilitate organellar diversification and to understand which apply to the NE, we exploited proteomic datasets of purified nuclear envelopes from model systems for comparative analysis. We find enrichment of core nuclear functions amongst the widely conserved proteins to be less numerous than lineage-specific cohorts, but enriched in core nuclear functions. This, together with consideration of additional evidence, suggests that, despite a common origin, the NE has evolved as a highly diverse organelle with significant lineage-specific functionality.
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