Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities.
Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities.
复制标题
DOI：
10.3390/pathogens10080967
复制
发表时间：
2021-07-30
期刊：
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Li B;Zhao Y
布氏锥虫引起人类非洲锥虫病，并定期转换其主要表面抗原，变异表面糖蛋白（VSG），以逃避宿主的免疫反应。这种抗原变异是T.布氏杆菌建立长期感染。VSG以严格的单等位基因方式仅从亚端粒位点表达，DNA重组是VSG转换的重要途径。端粒和亚端粒结构的完整性由多个端粒蛋白维持，是T.布氏杆菌活力和调节单等位基因VSG表达和VSG转换。在这里，我们将重点放在T。综述了布氏杆菌TRF和RAP 1这两种具有独特核酸结合活性的端粒蛋白在端粒完整性和稳定性、VSG转换和单等位基因VSG表达中的功能。针对TbTRF和TbRAP 1的核酸结合活性的独特特征，干扰端粒结构的完整性和破坏VSG单等位基因的表达，可能成为抗T.布鲁塞。
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere proteins with unique nucleic acid binding activities, and summarize their functions in telomere integrity and stability, VSG switching, and monoallelic VSG expression. Targeting the unique features of TbTRF and TbRAP1′s nucleic acid binding activities to perturb the integrity of telomere structure and disrupt VSG monoallelic expression may serve as potential therapeutic strategy against T. brucei.
登录
查看更多内容
影响因子：
7.7
作者：
Batram C;Jones NG;Janzen CJ;Markert SM;Engstler M
通讯作者：
Engstler M
影响因子：
14.9
作者：
Bhattacharjee A;Wang Y;Diao J;Price CM
通讯作者：
Price CM
影响因子：
4.5
作者：
Bhattacharjee A;Stewart J;Chaiken M;Price CM
通讯作者：
Price CM
影响因子：
14.9
作者：
Bah A;Wischnewski H;Shchepachev V;Azzalin CM
通讯作者：
Azzalin CM
影响因子：
1.5
作者：
Barry, JD;Graham, SV;Wymer, B
通讯作者：
Wymer, B