Association between total bilirubin and hemoglobin A1c in Korean type 2 diabetic patients.
Association between total bilirubin and hemoglobin A1c in Korean type 2 diabetic patients.
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DOI：
10.3346/jkms.2012.27.10.1196
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发表时间：
2012-10
影响因子：
4.5
通讯作者：
Shin MH
中科院分区：
文献类型：
--
作者：
Choi SW;Lee YH;Kweon SS;Song HR;Ahn HR;Rhee JA;Choi JS;Shin MH
最近的研究表明，在一般人群中，胆红素与血红蛋白A1 c（HbA 1c）呈负相关。糖尿病患者血清中胆红素和HbA 1c之间的相关性尚未研究。本研究的目的是评估韩国2型糖尿病患者总胆红素和HbA 1c之间的相关性。在杰奥拉南-做的西区、光州和极城郡的公共卫生中心登记的1，275名2型糖尿病患者中，共有690名参与了本研究。禁食过夜后，采集静脉血和尿液样本并进行分析。校正其他混杂因素后，根据总胆红素（≤ 0.4 mg/dL，7.6%; 0.5 mg/dL，7.3%; 0.6-0.7 mg/dL，7.2%;和≥ 0.8 mg/dL，7.1%;趋势P = 0.016），平均HbA 1c值存在显著差异。当根据其他混杂因素调整比值比（OR）时，总胆红素与HbA 1c之间存在显著相关性（总胆红素≥ 0.8 mg/dL vs ≤ 0.4 mg/dL的OR为0.4 [95%置信区间为0.2-0.8]。总之，在2型糖尿病患者中，校正性别、年龄和其他混杂因素后，血清总胆红素浓度与HbA 1c水平呈负相关。
Recent studies have shown that bilirubin is negatively associated with hemoglobin A1c (HbA1c) in the general population. The association between bilirubin and HbA1c in serum of diabetes patients has not yet been studied. The aim of the present study was to evaluate the association between total bilirubin and HbA1c in Korean patients with type 2 diabetes. A total of 690 of the 1,275 type 2 diabetes patients registered with the public health centers in Seo-gu, Gwangju and Gokseong-gun, Jeollanam-do participated in this study. Following an overnight fast, venous blood and urine samples were collected and analyzed. The mean HbA1c values differed significantly according to total bilirubin (≤ 0.4 mg/dL, 7.6%; 0.5 mg/dL, 7.3%; 0.6-0.7 mg/dL, 7.2%; and ≥ 0.8 mg/dL, 7.1%; P for trend = 0.016) after we adjusted for other confounding factors. When the odds ratio (OR) was adjusted for other confounding factors, there was a significant association between total bilirubin and HbA1c (OR, 0.4 [95% confidence interval, 0.2-0.8] for total bilirubin ≥ 0.8 mg/dL versus ≤ 0.4 mg/dL. In conclusion, total bilirubin concentrations in serum are negatively associated with HbA1c levels after adjustment for sex, age, and other confounding factors in type 2 diabetes patients.
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DOI：
10.1161/atvbaha.107.153262
发表时间：
2008-01-01
影响因子：
8.7
作者：
Perlstein, Todd S.;Pande, Reena L.;Creager, Mark A.
通讯作者：
Creager, Mark A.
影响因子：
16.2
作者：
STAMLER, J;VACCARO, O;WENTWORTH, D
通讯作者：
WENTWORTH, D
影响因子：
9.8
作者：
Ceriello, A
通讯作者：
Ceriello, A
影响因子：
39.2
作者：
Selvin, E;Marinopoulos, S;Golden, SH
通讯作者：
Golden, SH
影响因子：
4.5
作者：
Chin HJ;Song YR;Kim HS;Park M;Yoon HJ;Na KY;Kim Y;Chae DW;Kim S
通讯作者：
Kim S