Differentiation of malignant and benign breast lesions using magnetization transfer imaging and dynamic contrast-enhanced MRI.
Differentiation of malignant and benign breast lesions using magnetization transfer imaging and dynamic contrast-enhanced MRI.
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DOI：
10.1002/jmri.23786
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发表时间：
2013-01
影响因子：
4.4
通讯作者：
Kim, Sungheon
中科院分区：
文献类型：
--
作者：
Heller, Samantha L.;Moy, Linda;Lavianlivi, Sherlin;Moccaldi, Melanie;Kim, Sungheon
To evaluate feasibility of using magnetization transfer ratio (MTR) in conjunction with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for differentiation of benign and malignant breast lesions at 3 Tesla. This prospective study was IRB and HIPAA compliant. DCE-MRI scans followed by MT imaging were performed on 41 patients. Region of interests (ROI’s) were drawn on co-registered MTR and DCE post-contrast images for breast structures, including benign lesions (BL) and malignant lesions (ML). Initial enhancement ratio (IER) and delayed enhancement ratio (DER) were calculated, as were normalized MTR, DER and IER (NMTR, NDER, NIER) values. Diagnostic accuracy analysis was performed. Mean MTR in ML was lower than in BL (p <0.05); mean DER and mean IER in ML were significantly higher than in BL (p<0.01, p<0.001). NMTR, NDER, and NIER were significantly lower in ML versus BL (p<0.007, p<0.001, p<0.001). IER had highest diagnostic accuracy (77.6%), sensitivity (86.2%), and area under the ROC curve (.879). MTR specificity was 100%. Logistic regression modeling with NMTR and NIER yielded best results for BL versus ML (sensitivity 93.1%, specificity 80%, AUC 0.884, accuracy 83.7%). Isolated quantitative DCE analysis may increase specificity of breast MR for differentiating BL and ML. DCE-MRI with NMTR may produce a robust means of evaluating breast lesions.
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