Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.
Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.
复制标题
炎症中白细胞-内皮相互作用的小 GTP 依赖性调节。
DOI：
10.1042/bst20170530
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发表时间：
2018
影响因子：
3.9
通讯作者：
Chu JY
中科院分区：
文献类型：
--
作者：
Chu JY
炎症是一种复杂的生物反应，其用于在有害刺激（例如感染、刺激或损伤）后保护身体组织并启动组织修复。在炎症反应开始时，促炎介质诱导血管内皮衬里和白细胞的变化。这导致血管通透性增加和粘附蛋白表达增加，并促进白细胞，特别是中性粒细胞与内皮细胞的粘附。粘附是中性粒细胞外渗和趋化因子刺激的募集到炎症部位的先决条件，其中中性粒细胞吞噬并杀死微生物，释放炎症介质并与其他免疫细胞相互作用以协调免疫应答，为组织修复做准备。许多信号传导蛋白质关键性地参与支持炎症反应和内皮细胞与白细胞之间的串扰的复杂信号传导过程。作为细胞-细胞和细胞-基质粘附的关键调节剂，小GTP酶（鸟苷三磷酸酶）作为嗜中性粒细胞-内皮细胞相互作用以及中性粒细胞募集到炎症部位的重要控制。在这里，我们总结了在这些早期炎症事件中依赖于白细胞中的小GTP酶的关键过程。我们特别关注整合素依赖性事件的调节及其在中性粒细胞粘附、趋化和募集过程中由Rho和Rap家族GTP酶及其调节剂的控制。
Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators induce changes in the endothelial lining of the blood vessels and in leukocytes. This results in increased vascular permeability and increased expression of adhesion proteins, and promotes adhesion of leukocytes, especially neutrophils to the endothelium. Adhesion is a prerequisite for neutrophil extravasation and chemoattractant-stimulated recruitment to inflammatory sites, where neutrophils phagocytose and kill microbes, release inflammatory mediators and cross-talk with other immune cells to co-ordinate the immune response in preparation for tissue repair. Many signalling proteins are critically involved in the complex signalling processes that underpin the inflammatory response and cross-talk between endothelium and leukocytes. As key regulators of cell–cell and cell–substratum adhesion, small GTPases (guanosine triphosphatases) act as important controls of neutrophil-endothelial cell interactions as well as neutrophil recruitment to sites of inflammation. Here, we summarise key processes that are dependent upon small GTPases in leukocytes during these early inflammatory events. We place a particular focus on the regulation of integrin-dependent events and their control by Rho and Rap family GTPases as well as their regulators during neutrophil adhesion, chemotaxis and recruitment.
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影响因子：
20.3
作者：
Jennings, Richard T.;Strengert, Monika;Knaus, Ulla G.
通讯作者：
Knaus, Ulla G.
影响因子：
8.8
作者：
Yuan Q;Ren C;Xu W;Petri B;Zhang J;Zhang Y;Kubes P;Wu D;Tang W
通讯作者：
Tang W
影响因子：
20.3
作者：
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通讯作者：
Vermeren, Sonja
影响因子：
32.4
作者：
Giagulli, C;Scarpini, E;Laudanna, C
通讯作者：
Laudanna, C
影响因子：
30.5
作者：
Katagiri, K;Maeda, A;Kinashi, T
通讯作者：
Kinashi, T