Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients.
Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients.
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中国患者恶性和感染性疾病中可溶性主要组织相容性复合物 I 类相关链 A 蛋白的升高
DOI：
10.1186/1471-2172-13-62
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发表时间：
2012-11-26
期刊：
影响因子：
3
通讯作者：
Cao R
中科院分区：
文献类型：
--
作者：
Jiang X;Huang JF;Huo Z;Zhang Q;Jiang Y;Wu X;Li Y;Jiang G;Zeng L;Yan XX;Yu P;Cao R
背景血清中可溶性主要组织相容性复合物 I 类链相关基因 A (sMICA) 产物的升高与组织/器官移植、自身免疫性疾病和一些恶性疾病有关。被微生物病原体感染的细胞可能会释放 sMICA，而在传染病中血清 sMICA 水平是否会发生变化以及在多大程度上会发生变化尚不清楚。方法本研究通过酶联免疫吸附试验 (ELISA) 测定了中国南方人群的血清 sMICA 水平，其中包括患有多种类型的恶性和传染病的患者 (n = 1041) 和健康对照 (n = 141)。 sMICA 升高在肝癌患者中显着，并且在肺癌、胃癌和鼻咽癌患者中接近统计学显着性。 sMICA升高还与一些细菌（肠杆菌科、结核分枝杆菌、非发酵革兰氏阴性菌和革兰氏阳性球菌）、病毒（乙型和丙型肝炎）和梅毒微螺旋体感染有关。结论血清sMICA水平可能对某些恶性和感染性疾病的诊断提供信息。结果还表明，在使用该测试评估其他疾病（例如癌症、宿主移植物反应和自身免疫性疾病）的状态时，应将微生物感染视为导致血清 sMICA 升高的潜在混杂临床状况。
BackgroundElevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious diseases.MethodsThe present study determined serum sMICA levels by enzyme-linked immunosorbent assay (ELISA) in a southern China population, including patients (n = 1041) suffering from several types of malignant and infectious diseases and healthy controls (n = 141).ResultsRelative to controls, serum sMICA elevation was significant in patients of hepatic cancer, and was approaching statistical significance in patients with lung, gastric and nasopharyngeal cancers. sMICA elevation was also associated with some bacterial (Enterobacteriaceae, Mycobacterium tuberculosis, non-fermenting Gram-negative bacteria and Gram-positive cocci), viral (hepatitis B and C) and the Microspironema pallidum infections.ConclusionSerum sMICA levels may be informative for the diagnosis of some malignant and infectious diseases. The results also indicate that microbiological infections should be considered as a potential confounding clinical condition causing serum sMICA elevation while using this test to evaluate the status of other disorders, such as cancers, host-graft response and autoimmune diseases.
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