Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy.
Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy.
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线粒体功能障碍和怀孕的急性脂肪肝。
DOI：
10.3390/ijms23073595
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发表时间：
2022-03-25
影响因子：
5.6
通讯作者：
Ibdah JA
中科院分区：
文献类型：
--
作者：
Ramanathan R;Ibdah JA
The liver is one of the richest organs in mitochondria, serving as a hub for key metabolic pathways such as β-oxidation, the tricarboxylic acid (TCA) cycle, ketogenesis, respiratory activity, and adenosine triphosphate (ATP) synthesis, all of which provide metabolic energy for the entire body. Mitochondrial dysfunction has been linked to subcellular organelle dysfunction in liver diseases, particularly fatty liver disease. Acute fatty liver of pregnancy (AFLP) is a life-threatening liver disorder unique to pregnancy, which can result in serious maternal and fetal complications, including death. Pregnant mothers with this disease require early detection, prompt delivery, and supportive maternal care. AFLP was considered a mysterious illness and though its pathogenesis has not been fully elucidated, molecular research over the past two decades has linked AFLP to mitochondrial dysfunction and defects in fetal fatty-acid oxidation (FAO). Due to deficient placental and fetal FAO, harmful 3-hydroxy fatty acid metabolites accumulate in the maternal circulation, causing oxidative stress and microvesicular fatty infiltration of the liver, resulting in AFLP. In this review, we provide an overview of AFLP and mitochondrial FAO followed by discussion of how altered mitochondrial function plays an important role in the pathogenesis of AFLP.
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DOI：
10.4137/jcd.s39824
发表时间：
2016
期刊：
Journal of cell death
影响因子：
--
作者：
Cao L;Quan XB;Zeng WJ;Yang XO;Wang MJ
通讯作者：
Wang MJ
影响因子：
25.7
作者：
Akazawa Y;Cazanave S;Mott JL;Elmi N;Bronk SF;Kohno S;Charlton MR;Gores GJ
通讯作者：
Gores GJ
DOI：
10.1155/2013/730569
发表时间：
2013
期刊：
ISRN obstetrics and gynecology
影响因子：
--
作者：
Dwivedi S;Runmei M
通讯作者：
Runmei M
线粒体融合启动子以视神经萎缩1依赖性方式恢复线粒体动力学平衡并改善糖尿病心肌病
影响因子：
6.3
作者：
Ding, Mingge;Liu, Chaoyang;Mi, Mantian
通讯作者：
Mi, Mantian
影响因子：
5.1
作者：
Ibdah, JA;Zhao, YW;Strauss, AW
通讯作者：
Strauss, AW