Control of Mycoplasma hyopneumoniae infections in pigs.
Control of Mycoplasma hyopneumoniae infections in pigs.
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DOI：
10.1016/j.vetmic.2007.09.008
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发表时间：
2008-01-25
影响因子：
3.3
通讯作者：
Haesebrouck F
中科院分区：
文献类型：
--
作者：
Maes D;Segales J;Meyns T;Sibila M;Pieters M;Haesebrouck F
猪肺炎支原体是地方性肺炎的主要病原体，在世界范围内广泛存在，给养猪业造成重大经济损失。这种生物附着并破坏呼吸道的纤毛上皮。受影响的猪表现出慢性咳嗽，更容易受到其他呼吸道感染，表现下降。这种疾病的控制可以通过多种方式实现。首先，要优化畜群的管理做法和居住条件。这些措施包括全力以赴/全力以赴的生产、可能破坏群体免疫稳定的限制因素、保持最佳的放牧密度、预防其他呼吸道疾病以及最佳的住房和气候条件。在猪有呼吸道疾病风险的时期，使用抗猪肺炎支原体的战略药物，最好也是抗主要次级细菌的药物，可能是有用的。最后，商业细菌素被广泛用于控制猪肺炎支原体感染。接种疫苗的主要效果包括减少临床症状、肺部损害和药物使用，并改善性能。然而，细菌素只能提供部分保护，并不能阻止生物体的定植。根据猪群的类型、生产系统和管理做法、感染模式和养猪者的喜好，可以使用不同的疫苗接种策略(接种时间、母猪接种、疫苗接种与抗菌药物相结合)。对新疫苗的研究正在积极进行，包括气雾剂疫苗和饲料疫苗以及亚单位疫苗和DNA疫苗。根据年龄隔离和药物治疗在畜群一级根除感染是可能的，但再次感染的风险是永久性的。
Mycoplasma hyopneumoniae, the primary pathogen of enzootic pneumonia, occurs worldwide and causes major economic losses to the pig industry. The organism adheres to and damages the ciliated epithelium of the respiratory tract. Affected pigs show chronic coughing, are more susceptible to other respiratory infections and have a reduced performance. Control of the disease can be accomplished in a number of ways. First, management practices and housing conditions in the herd should be optimized. These include all-in/all-out production, limiting factors that may destabilize herd immunity, maintaining optimal stocking densities, prevention of other respiratory diseases, and optimal housing and climatic conditions. Strategic medication with antimicrobials active against M. hyopneumoniae and, preferably, also against major secondary bacteria may be useful during periods when the pigs are at risk for respiratory disease. Finally, commercial bacterins are widely used to control M. hyopneumoniae infections. The main effects of vaccination include less clinical symptoms, lung lesions and medication use, and improved performance. However, bacterins provide only partial protection and do not prevent colonization of the organism. Different vaccination strategies (timing of vaccination, vaccination of sows, vaccination combined with antimicrobial medication) can be used, depending on the type of herd, the production system and management practices, the infection pattern and the preferences of the pig producer. Research on new vaccines is actively occurring, including aerosol and feed-based vaccines as well as subunit and DNA vaccines. Eradication of the infection at herd level based on age-segregation and medication is possible, but there is a permanent risk for re-infections.
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
2.2
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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