A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease.
A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease.
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TNFSF4 多态性（rs3861950 T > C 和 rs1234313 A > G）与冠心病易感性关联的荟萃分析
DOI：
10.3389/fphys.2020.539288
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发表时间：
2020
影响因子：
4
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Liu S;Wang X;Yu S;Yan M;Peng Y;Zhang G;Xu Z
背景资料：冠状动脉疾病（CAD）仍然是全球死亡的主要原因，其易感性与基因修饰密切相关。炎症和CAD之间的关联已被详细研究。本荟萃分析基于PRISMA指南进行，以评估肿瘤坏死因子超家族成员4（TNFSF 4）基因多态性（rs3861950 T > C和rs1234313 A > G）与CAD风险之间的关联。研究方法：入选标准包括11篇合格文章，包含18项研究（9项研究包括rs3861950的7，395例病例和5，296例对照，9项研究包括rs1234313的6，951例病例和4，959例对照）。通过合并等位基因、显性、隐性、杂合和纯合模型中的比值比（OR）和95%置信区间（95%CI）来估计两种多态性与CAD之间的相关性。结果如下：汇总分析表明，rs3861950 T > C多态性与亚洲人群中等位基因模型、显性模型和纯合子模型中CAD风险增加显著相关。此外，基于疾病类型的亚组分析显示，TNFSF 4 rs3861950 T > C在等位基因模型、显性模型、杂合模型和纯合模型中与脑梗死（CI）风险增加具有稳健的相关性。然而，在等位基因和显性模型中，rs1234313 A > G多态性大多倾向于降低亚洲和高加索人群中CAD的风险。在等位基因模型、显性模型和杂合子模型中，该单核苷酸多态性（SNP）与心肌梗死（MI）易感性密切相关。结论：本荟萃分析发现TNFSF 4中两个新的SNP与CAD易感性显著相关。
Background: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, and its susceptibility is closely associated with genetic modifications. The association between inflammation and CAD has been investigated in detail. This meta-analysis was conducted based on the PRISMA guidelines to evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3861950 T > C and rs1234313 A > G) and the risk of CAD. Methods: The selected criteria included 11 eligible articles containing 18 studies (nine studies included 7,395 cases and 5,296 controls for rs3861950 and nine studies with 6,951 cases and 4,959 controls for rs1234313). Correlations between the two polymorphisms and CAD were estimated by pooling the odds ratios (ORs) with 95% confidence interval (95% CI) in allelic, dominant, recessive, heterozygous, and homozygous models. Results: The pooled analyses demonstrated that the rs3861950 T > C polymorphism was significantly associated with an increased risk of CAD in the Asian population in the allelic model, dominant model, and homozygous model. Furthermore, subgroup analysis based on disease type showed that TNFSF4 rs3861950 T > C had a robust correlation with increased risk of cerebral infarction (CI) in the allelic model, dominant model, heterozygous model, and homozygous model. However, the rs1234313 A > G polymorphism mostly tended to decrease the risk of CAD in the Asian and Caucasian populations in the allelic and dominant model. This single nucleotide polymorphism (SNP) had a close relation to myocardial infarction (MI) susceptibility in the allelic model, dominant model, and heterozygous model. Conclusion: This meta-analysis identified two novel SNPs in TNFSF4 significantly associated with CAD susceptibility.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
2.7
作者：
Cheng, Guanghui;Wang, Hui;Liu, Qiji
通讯作者：
Liu, Qiji
DOI：
10.1073/pnas.0705041104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Desai, Urvi;Lee, E-Chiang;Powell, David R.
通讯作者：
Powell, David R.
影响因子：
158.5
作者：
Cohen, JC;Boerwinkle, E;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
0.4
作者：
Cheng, J.;Cen, J. -M.;Xiong, X. -D.
通讯作者：
Xiong, X. -D.