Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review.
Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review.
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在非酒精性脂肪肝和代谢综合征中添加果糖：叙述性评论。
DOI：
10.3390/nu14061127
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发表时间：
2022-03-08
期刊：
影响因子：
5.9
通讯作者：
Del Ben M
中科院分区：
文献类型：
--
作者：
Coronati M;Baratta F;Pastori D;Ferro D;Angelico F;Del Ben M
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病，被认为是代谢综合征（MetS）的肝脏表现。饮食是NAFLD和MetS治疗的关键因素，但一些营养素可能在其病理生理学中发挥作用。其中，通过高果糖玉米糖浆（HFCS）和蔗糖添加到食物中的果糖可能参与NAFLD和MetS的发生和发展。果糖诱导从头脂肪生成（DNL）、内质网应激和肝脏炎症，促进胰岛素抵抗和血脂异常。果糖还通过过量生产丙二酰辅酶A减少脂肪酸氧化，促进脂肪变性。此外，最近的研究表明，与果糖消耗相关的肠道通透性变化有助于NAFLD和MetS的风险。最后，饥饿-饱足感机制和尿酸合成的改变分别将果糖摄入与体重增加和高血压联系起来。然而，需要进一步的研究来更好地评估果糖和代谢性疾病之间的因果关系，并开发针对NAFLD和MetS的新的治疗和预防策略。
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease and it is considered the hepatic manifestation of metabolic syndrome (MetS). Diet represents the key element in NAFLD and MetS treatment, but some nutrients could play a role in their pathophysiology. Among these, fructose added to foods via high fructose corn syrup (HFCS) and sucrose might participate in NAFLD and MetS onset and progression. Fructose induces de novo lipogenesis (DNL), endoplasmic reticulum stress and liver inflammation, promoting insulin resistance and dyslipidemia. Fructose also reduces fatty acids oxidation through the overproduction of malonyl CoA, favoring steatosis. Furthermore, recent studies suggest changes in intestinal permeability associated with fructose consumption that contribute to the risk of NAFLD and MetS. Finally, alterations in the hunger–satiety mechanism and in the synthesis of uric acid link the fructose intake to weight gain and hypertension, respectively. However, further studies are needed to better evaluate the causal relationship between fructose and metabolic diseases and to develop new therapeutic and preventive strategies against NAFLD and MetS.
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影响因子：
4.7
作者：
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DOI：
10.1136/bmj.k4644
发表时间：
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期刊：
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影响因子：
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