Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles.
Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles.
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通过与金纳米粒子缀合增强胆汁酸顺铂衍生物的细胞毒活性。
DOI：
10.1016/j.jinorgbio.2013.10.021
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发表时间：
2014
影响因子：
3.9
通讯作者：
M. Fuentes
中科院分区：
文献类型：
--
作者：
Sara Sánchez‐Paradinas;M. Pérez‐Andrés;M. Almendral;E. Rodríguez;Á. Millán;F. Palacio;A. Órfão;J. Criado;M. Fuentes
本文探讨了潜在的细胞毒性活性的胆汁酸顺铂衍生物，如双熊去氧胆酸盐（乙二胺）铂（II），PtU 2，当共轭与金纳米粒子，是一个有前途的替代顺铂在治疗癌症，由于其较低的毒性。为了我们的目的，我们分析了这些化合物在MG 63（骨肉瘤）细胞系中与20 nm金纳米颗粒（PtU 2-AuNPs）缀合后的细胞内递送能力。在铂-金纳米颗粒缀合物的情况下，与PtU 2和PtU 2-AuNP衍生物孵育后相同的铂摄取与更高的细胞毒性活性相关，对于这些新缀合物，PtU 2的总IC 50降低超过10倍。当与金纳米颗粒缀合时，该胆汁酸衍生物在其细胞毒性活性方面比单独的铂化合物更有效。
This article explores the potential cytotoxic activity of bile-acid cisplatin derivatives like bisursodeoxycholate(ethylenediamine)platinum(II), PtU2, when conjugated with gold nanoparticles, being a promising alternative to cisplatin in the treatment of cancer due to their lower toxicity. For our purpose we analyzed the intracellular delivery ability of these compounds after conjugation with 20-nm gold nanoparticles (PtU2-AuNPs) in the MG63 (osteosarcoma) cell line. Same platinum uptake after incubation with PtU2 and PtU2-AuNPs-derivatives is associated with a higher cytotoxic activity in case of the platinum–gold nanoparticle conjugate, the overall IC50 of PtU2 being reduced more than 10 fold for these new conjugates. When conjugated with gold nanoparticles, this bile-acid derivative is more efficient than the platinum compound alone in terms of their cytotoxic activity.
DOI：
10.1073/pnas.95.8.4607
发表时间：
1998-04-14
影响因子：
11.1
作者：
Hobbs, SK;Monsky, WL;Jain, RK
通讯作者：
Jain, RK
影响因子：
11.2
作者：
Fan Yuan;M. Dellian;D. Fukumura;M. Leunig;D. Berk;V. Torchilin;R. Jain
通讯作者：
Fan Yuan;M. Dellian;D. Fukumura;M. Leunig;D. Berk;V. Torchilin;R. Jain
影响因子：
16.1
作者：
Rana, Subinoy;Bajaj, Avinash;Mout, Rubul;Rotello, Vincent M.
通讯作者：
Rotello, Vincent M.