Monolayer coated gold nanoparticles for delivery applications.

Monolayer coated gold nanoparticles for delivery applications.
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DOI:
10.1016/j.addr.2011.08.006
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发表时间:
2012-02
影响因子:
16.1
通讯作者:
Rotello, Vincent M.
Rotello, Vincent M.
中科院分区:
医学1区
文献类型:
--
作者:
Rana, Subinoy;Bajaj, Avinash;Mout, Rubul;Rotello, Vincent M.

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Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity coupled with the ability to parametrically control particle size and surface properties. In this review, we focus on engineering of the AuNP surface monolayer, highlighting recent advances in tuning monolayer structures for efficient delivery of drugs and biomolecules. This review covers two broad categories of particle functionalization, organic monolayers and biomolecule coatings, and discusses their applications in drug, DNA/RNA, protein and small molecule delivery.
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