Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia.
Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia.
复制标题
癌症恶病质期间营养品和运动对抗肌肉消耗。
DOI：
10.3390/cells9122536
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发表时间：
2020-11-24
期刊：
影响因子：
6
通讯作者：
Piccirillo R
中科院分区：
文献类型：
--
作者：
Aquila G;Re Cecconi AD;Brault JJ;Corli O;Piccirillo R
癌症恶病质(CC)是一种多因素衰弱综合征，涉及骨骼肌进行性恶化和功能损害。它影响了大约80%的晚期癌症患者，并导致过早死亡。目前尚无针对CC的因果治疗方法。在过去的几十年里，我们对癌症期间肌肉萎缩的机制的了解有了显著的提高。炎症和氧化应激(OS)都改变了合成代谢和分解代谢的信号通路，主要以肌肉衰竭为最终结果。一些临床前研究强调了几类营养食品和体育锻炼模式的有益作用，但它们对CC患者的疗效仍然很少。营养制剂的给药途径对于提高其生物利用度和达到预期的抗恶病质效果至关重要。越来越多的证据表明，单一疗法可能还不够，双模式干预(营养食品加运动)可能是治疗CC的更有效的方法。本文就炎症和OS在CC肌肉萎缩发病机制中的作用，以及营养食品和运动如何协同作用来限制肌肉损耗和功能障碍的研究现状进行综述。
Cancer cachexia (CC) is a debilitating multifactorial syndrome, involving progressive deterioration and functional impairment of skeletal muscles. It affects about 80% of patients with advanced cancer and causes premature death. No causal therapy is available against CC. In the last few decades, our understanding of the mechanisms contributing to muscle wasting during cancer has markedly increased. Both inflammation and oxidative stress (OS) alter anabolic and catabolic signaling pathways mostly culminating with muscle depletion. Several preclinical studies have emphasized the beneficial roles of several classes of nutraceuticals and modes of physical exercise, but their efficacy in CC patients remains scant. The route of nutraceutical administration is critical to increase its bioavailability and achieve the desired anti-cachexia effects. Accumulating evidence suggests that a single therapy may not be enough, and a bimodal intervention (nutraceuticals plus exercise) may be a more effective treatment for CC. This review focuses on the current state of the field on the role of inflammation and OS in the pathogenesis of muscle atrophy during CC, and how nutraceuticals and physical activity may act synergistically to limit muscle wasting and dysfunction.
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影响因子：
--
作者：
Aggarwal, Bharat;Prasad, Sahdeo;Sung, Bokyung;Krishnan, Sunil;Guha, Sushovan
通讯作者：
Guha, Sushovan
影响因子：
--
作者：
Arcidiacono B;Iiritano S;Nocera A;Possidente K;Nevolo MT;Ventura V;Foti D;Chiefari E;Brunetti A
通讯作者：
Brunetti A
影响因子：
8.9
作者：
Aniort, Julien;Stella, Alexandre;Taillandier, Daniel
通讯作者：
Taillandier, Daniel
影响因子：
4.8
作者：
Abrigo, Johanna;Carlos Rivera, Juan;Cabello-Verrugio, Claudio
通讯作者：
Cabello-Verrugio, Claudio
DOI：
10.1093/jnci/djw153
发表时间：
2016-11
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Allen NE;Travis RC;Appleby PN;Albanes D;Barnett MJ;Black A;Bueno-de-Mesquita HB;Deschasaux M;Galan P;Goodman GE;Goodman PJ;Gunter MJ;Heliövaara M;Helzlsouer KJ;Henderson BE;Hercberg S;Knekt P;Kolonel LN;Lasheras C;Linseisen J;Metter EJ;Neuhouser ML;Olsen A;Pala V;Platz EA;Rissanen H;Reid ME;Schenk JM;Stampfer MJ;Stattin P;Tangen CM;Touvier M;Trichopoulou A;van den Brandt PA;Key TJ;Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group
通讯作者：
Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group