Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder.
Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder.
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DOI：
10.1542/peds.2009-0015
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发表时间：
2009-10
期刊：
影响因子：
8
通讯作者：
Leckman JF
中科院分区：
文献类型：
--
作者：
Bloch MH;Craiglow BG;Landeros-Weisenberger A;Dombrowski PA;Panza KE;Peterson BS;Leckman JF
本研究的目的是确定儿童期发病的强迫症（OCD）早期成人结局的儿童期临床预测因子，并评估OCD的维度亚型和共病抽动症状的存在是否影响长期结局。我们进行了一项纵向队列研究，其中62名符合条件的强迫症儿童中有45名在平均9年后的成年早期重新评估。主要结果测量包括专家评定、强迫症（OC）症状严重程度和OC症状缓解时间。基线临床特征在其对成年期强迫症严重程度的影响和OC症状缓解时间方面进行了评估。44%的受试者在随访评估时被确定为具有亚临床OC症状。没有共病抽动障碍和存在明显的囤积症状与强迫症症状的持续存在有关。女性、儿童期评估年龄较早、强迫症发病年龄较晚、儿童期强迫症症状较严重以及共病对立违抗性障碍也与强迫症症状持续至成年相关。这些结果证实，一个显着比例的治疗儿童强迫症的经验缓解成年。共病抽搐的存在预示着积极的结果，而原发性囤积症状与持续的强迫症有关。
The aim of this study was to determine the childhood clinical predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder (OCD) and to assess whether dimensional subtypes of OCD and the presence of comorbid tic symptoms influence long-term outcomes. We conducted a longitudinal cohort study in which 45 of 62 eligible children with OCD were reassessed an average of 9 years later, in early adulthood. Main outcome measures included expert-rated, obsessive-compulsive (OC) symptom severity and time to remission of OC symptoms. Baseline clinical characteristics were evaluated in terms of their influence on OCD severity in adulthood and time to remission of OC symptoms. Forty-four percent of subjects were determined to have subclinical OC symptoms at the follow-up evaluation. The absence of a comorbid tic disorder and the presence of prominent hoarding symptoms were associated with the persistence of OCD symptoms. Female gender, earlier age at childhood assessment, later age of OCD onset, more-severe childhood OCD symptoms, and comorbid oppositional defiant disorder also were associated with persistence of OCD symptoms into adulthood. These results confirm that a significant proportion of treated children with OCD experience remission by adulthood. The presence of comorbid tics heralds a positive outcome, whereas primary hoarding symptoms are associated with persistent OCD.
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DOI：
10.1176/appi.ajp.2008.08020320
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bloch MH;Landeros-Weisenberger A;Rosario MC;Pittenger C;Leckman JF
通讯作者：
Leckman JF
影响因子：
22.8
作者：
Mataix-Cols, D;Marks, IM;Baer, L
通讯作者：
Baer, L
影响因子：
--
作者：
Mataix-Cols, D;Wooderson, S;Phillips, ML
通讯作者：
Phillips, ML
DOI：
10.1089/104454603322126313
发表时间：
2003-01-01
影响因子：
1.9
作者：
Geller, DA;Biederman, J;Carpenter, D
通讯作者：
Carpenter, D
影响因子：
11.3
作者：
Hasler, G;LaSalle-Ricci, VH;Murphy, DL
通讯作者：
Murphy, DL