Prevalence and possible causes of hypouricemia at a tertiary care hospital.
Prevalence and possible causes of hypouricemia at a tertiary care hospital.
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第三纪念医院患病率和可能导致低血血症的原因。
DOI：
10.3904/kjim.2015.125
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Jun JB
中科院分区：
文献类型：
--
作者：
Son CN;Kim JM;Kim SH;Cho SK;Choi CB;Sung YK;Kim TH;Bae SC;Yoo DH;Jun JB
我们的目的是调查韩国人群中低尿酸血症的患病率和可能的原因，并将我们的研究结果与其他人群的研究结果进行比较。我们检查了30，757名受试者的血清尿酸水平，这些受试者在1年内至少测量了一次尿酸值。对所有患有低尿酸血症（血清尿酸< 2.0 mg/dL，n = 424）的个体进行了既往确定为与低尿酸血症相关的病史和伴随疾病的审查。住院患者低尿酸血症患病率为4.14%（299/7，223），门诊患者低尿酸血症患病率为0.53%（125/23，534），总患病率为1.39%（424/30，757）。与低尿酸血症相关的可能原因包括实体瘤或恶性血液病（n = 86）、糖尿病（n = 56）和治疗药物（n = 29）。药物为别嘌呤醇（n = 11）、血管紧张素II受体阻滞剂（n = 10）、水杨酸盐（n = 6）、非布司他（n = 1）和华法林（n = 1）。在其余226人中，未确定低尿酸血症的原因。与其他国家相比，低尿酸血症在韩国人群中相对常见。与低尿酸血症相关的可能原因与基础疾病和药物有关。
We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.
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影响因子：
13.2
作者：
Bairaktari, ET;Kakafika, AI;Elisaf, MS
通讯作者：
Elisaf, MS
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
2.5
作者：
Lee, Joo Hoon;Choi, Hyun Jin;Cheong, Hae Il
通讯作者：
Cheong, Hae Il
影响因子：
--
作者：
Bugdayci, Guler;Balaban, Yasemin;Sahin, Ozlem
通讯作者：
Sahin, Ozlem
重复运动引起的运动引起的急性肾衰竭，患有严重的肾脏低血症和SLC2A9复合杂合性的年轻男子。
影响因子：
--
作者：
Jeannin G;Chiarelli N;Gaggiotti M;Ritelli M;Maiorca P;Quinzani S;Verzeletti F;Possenti S;Colombi M;Cancarini G
通讯作者：
Cancarini G