Evolution of karyotypes in philadelphia (Ph1) chromosome‐negative chronic myelogenous leukemia
Evolution of karyotypes in philadelphia (Ph1) chromosome‐negative chronic myelogenous leukemia
复制标题
费城 (Ph1) 染色体阴性慢性粒细胞白血病核型的演变
作者：
U. Mintz;J. Vardiman;H. Golomb;J. Rowley
在1972至1977年间诊断的55例慢性粒细胞白血病(CML)患者中，有10例发现缺少费城(PH1)染色体。对PH1阴性的CML患者进行的一系列临床、形态和细胞遗传学研究显示，其中30%的患者有染色体异常。其中两人在白血病危象发生时有一条额外的8号染色体，并有一张骨髓中成髓细胞的形态图片。第三名患者最初的易位为6：14。14号染色体异常常见于淋巴增生性疾病，骨髓和外周血中含有大量的淋巴母细胞和成髓细胞。10例患者的中位生存期为19个月。PH1阴性的慢性粒细胞白血病的确切性质尚不清楚；该疾病似乎是骨髓增生性疾病中的一个独特实体。癌症43：411-416,1979。
Ten of 55 patients with chronic myelogenous leukemia (CML) diagnosed between 1972 and 1977 were found to lack the Philadelphia (Ph1) chromosome. Serial clinical, morphologic, and cytogenetic studies of patients with Ph1 negative CML showed that 30% of them had chromosomal abnormalities. Two had an extra chromosome No. 8 at the time of blast crisis, with a morphological picture of myeloblasts in the bone marrow. A third patient had a 6:14 translocation initially. Abnormalities of chromosome No. 14 are frequently seen in lymphoproliferative disorders, and the bone marrow and peripheral blood contained a significant population of lymphoblasts as well as myeloblasts. The median survival for the 10 patients was 19 months. The exact nature of Ph1‐negative CML is not yet clear; the disease appears to be a distinct entity among the myeloproliferative disorders. Cancer 43:411–416, 1979.
影响因子：
3.1
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman