Enhanced protection against malaria by indoor residual spraying in addition to insecticide treated nets: is it dependent on transmission intensity or net usage?
Enhanced protection against malaria by indoor residual spraying in addition to insecticide treated nets: is it dependent on transmission intensity or net usage?
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DOI：
10.1371/journal.pone.0115661
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kleinschmidt I
中科院分区：
文献类型：
--
作者：
West PA;Protopopoff N;Wright A;Kivaju Z;Tigererwa R;Mosha FW;Kisinza W;Rowland M;Kleinschmidt I
经杀虫剂处理的蚊帐 (ITN) 和室内滞留喷洒 (IRS) 是预防疟疾的有效病媒控制工具。关于结合使用 ITN 和 IRS 是否比单独使用这两种方法中的任何一种提供更多好处，存在相互矛盾的证据。本研究调查了与单独使用驱虫蚊帐相比，可能改变联合使用 IRS 和驱虫蚊帐对疟疾感染流行率的影响的因素。对坦桑尼亚西北部一项整群随机试验的数据进行了二次分析。 50 个集群通过全民覆盖活动获得了驱虫蚊帐；其中 25 人被随机分配，在 2012 年另外接受两轮 IRS。在横断面家庭调查中，0.5-14 岁的儿童在第一轮 IRS 后的 2、6 和 10 个月接受了恶性疟原虫感染 (PfPR) 检测。 IRS 保护那些睡在蚊帐下的人（OR = 0.38，95%CI 0.26–0.57）和那些没有睡在蚊帐下的人（OR = 0.43，95%CI 0.29–0.63）。 IRS 的保护作用并未因社区层面 ITN 使用而改变（ITN 使用<50%，OR = 0.39，95%CI 0.26–0.59；ITN 使用> = 50%，OR = 0.46，95%CI 0.28–0.74）。 IRS 的额外保护在低传播区域（<10% PfPR，OR = 0.38，95% CI 0.19–0.75）和高传播区域（≥10% PfPR，OR = 0.34，95% CI 0.18–0.67）相似。无论村庄是否已喷洒农药，驱虫蚊帐的使用在个人层面上都具有保护作用（OR = 0.83，95%CI 0.70–0.98）。无论个体昨晚是否在杀虫剂蚊帐下睡觉，生活在喷过喷雾的村庄都具有保护作用（OR = 0.41，95%CI 0.29–0.58）。除了驱虫蚊帐之外，实施 IRS 对于来自传播强度和净利用率水平各异的村庄的个人也是有益的。网络用户获得国税局的额外保护。即使在这个对拟除虫菊酯类杀虫剂具有高度抗药性的地区，驱虫蚊帐也提供了一些个人保护。这些结果表明，即使 ITN 有效，IRS 也能带来额外的好处。 ClinicalTrials.gov NCT01697852
Insecticide treated nets (ITNs) and indoor residual spraying (IRS) are effective vector control tools that protect against malaria. There is conflicting evidence regarding whether using ITNs and IRS in combination provides additional benefit over using either of these methods alone. This study investigated factors that may modify the effect of the combined use of IRS and ITNs compared to using ITNs alone on malaria infection prevalence. Secondary analysis was carried out on data from a cluster randomised trial in north-west Tanzania. 50 clusters received ITNs from a universal coverage campaign; of these 25 were randomly allocated to additionally receive two rounds of IRS in 2012. In cross-sectional household surveys children 0.5–14 years old were tested for Plasmodium falciparum infections (PfPR) two, six and ten months after the first IRS round. IRS protected those sleeping under nets (OR = 0.38, 95%CI 0.26–0.57) and those who did not (OR = 0.43, 95%CI 0.29–0.63). The protective effect of IRS was not modified by community level ITN use (ITN use<50%, OR = 0.39, 95%CI 0.26–0.59; ITN use> = 50%, OR = 0.46, 95%CI 0.28–0.74). The additional protection from IRS was similar in low (<10% PfPR, OR = 0.38, 95%CI 0.19–0.75) and high transmission areas (≥10% PfPR, OR = 0.34, 95%CI 0.18–0.67). ITN use was protective at the individual-level regardless of whether the village had been sprayed (OR = 0.83, 95%CI 0.70–0.98). Living in a sprayed village was protective regardless of whether the individual slept under an ITN last night (OR = 0.41, 95%CI 0.29–0.58). Implementing IRS in addition to ITNs was beneficial for individuals from villages with a wide range of transmission intensities and net utilisation levels. Net users received additional protection from IRS. ITNs were providing some individual protection, even in this area with high levels of pyrethroid insecticide resistance. These results demonstrate that there is a supplementary benefit of IRS even when ITNs are effective. ClinicalTrials.gov NCT01697852
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DOI：
10.4269/ajtmh.2009.81.519
发表时间：
2009-09-01
影响因子：
3.3
作者：
Kleinschmidt, Immo;Schwabe, Christopher;Coleman, Michael
通讯作者：
Coleman, Michael
影响因子：
3.5
作者：
Filmer, D;Pritchett, LH
通讯作者：
Pritchett, LH
影响因子：
56.3
作者：
Corbel, Vincent;Akogbeto, Martin;Henry, Marie-Claire
通讯作者：
Henry, Marie-Claire
影响因子：
15.8
作者：
Griffin, Jamie T.;Hollingsworth, T. Deirdre;Ghani, Azra C.
通讯作者：
Ghani, Azra C.
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW