The clinicopathological characteristics, prognosis and immune microenvironment mapping in MSI-H/MMR-D endometrial carcinomas.
The clinicopathological characteristics, prognosis and immune microenvironment mapping in MSI-H/MMR-D endometrial carcinomas.
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MSI-H/MMR-D子宫内膜癌的临床病理特征、预后和免疫微环境图谱
DOI：
10.1007/s12672-022-00466-5
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发表时间：
2022-03-03
影响因子：
2.2
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Guo YE;Liu Y;Zhang W;Luo H;Shu P;Chen G;Li Y
子宫内膜癌中MMR缺陷的患病率相对较高。MMR-D/MSI-H子宫内膜癌患者被认为是PD-1/PD-L1抑制剂治疗的潜在受益者。本文探讨MSI亚型在子宫内膜癌中的预后价值及其与免疫环境的关系。基于来自TCGA-UCEC项目的78例POLE、123例MSI和299例Other EC样本的表达和临床数据，我们发现MSI肿瘤更常在早期被识别，具有较低的年龄、更好的患者存活率、富集的CD 8 +T细胞和调节性T细胞以及比Other组更少的M2巨噬细胞和活化的树突状细胞，差异表达分析显示与POLE组比较有相似的表达谱。此外，我们使用3371个细胞的无偏单细胞RNA-seq分析建立了MMR-D子宫内膜癌组织的免疫景观。免疫组化结果显示，MMR-D肿瘤中CD 20 +B细胞浸润呈增高趋势。本研究为进一步了解免疫亚群在MSI子宫内膜癌中的作用提供了新的思路，并为子宫内膜癌的免疫治疗提供了指导。
Endometrial cancer had a relatively high prevalence of MMR deficiency. MMR-D/MSI-H endometrial cancer patients are suggested to be potential beneficiaries of PD-1/PD-L1 inhibitor therapy. Here, we explored the prognostic value of MSI subtype in endometrial cancer and its correlation with immune environment. Based on expression and clinical data of 78 POLE, 123 MSI and 299 Other EC samples from the TCGA-UCEC project, we found that the MSI tumors were identified more often in early stage, had a lower age, better patient survival, enriched CD8+T cells, and regulatory T cells and less M2 macrophages and activated dendritic cells than the Other group, and shared a relatively similar expression profile with POLE group by differential analysis. In addition, we established the immune landscape of an MMR-D endometrial cancer tissue using unbiased single-cell RNA-seq analysis of 3371 cells. By immunohistochemistry analysis, we found that the MMR-D tumors showed a higher trend of CD20+B cells infiltration. Our study might expand our understanding of the role of immune subsets in MSI endometrial carcinomas and provide guidance of immunotherapy for endometrial cancer.
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影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
影响因子：
16.6
作者：
MacParland SA;Liu JC;Ma XZ;Innes BT;Bartczak AM;Gage BK;Manuel J;Khuu N;Echeverri J;Linares I;Gupta R;Cheng ML;Liu LY;Camat D;Chung SW;Seliga RK;Shao Z;Lee E;Ogawa S;Ogawa M;Wilson MD;Fish JE;Selzner M;Ghanekar A;Grant D;Greig P;Sapisochin G;Selzner N;Winegarden N;Adeyi O;Keller G;Bader GD;McGilvray ID
通讯作者：
McGilvray ID
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.0903009
发表时间：
2010-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
DiLillo DJ;Yanaba K;Tedder TF
通讯作者：
Tedder TF
影响因子：
30.8
作者：
Gibson WJ;Hoivik EA;Halle MK;Taylor-Weiner A;Cherniack AD;Berg A;Holst F;Zack TI;Werner HM;Staby KM;Rosenberg M;Stefansson IM;Kusonmano K;Chevalier A;Mauland KK;Trovik J;Krakstad C;Giannakis M;Hodis E;Woie K;Bjorge L;Vintermyr OK;Wala JA;Lawrence MS;Getz G;Carter SL;Beroukhim R;Salvesen HB
通讯作者：
Salvesen HB