Volitional learning promotes theta phase coding in the human hippocampus.
Volitional learning promotes theta phase coding in the human hippocampus.
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DOI：
10.1073/pnas.2021238118
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发表时间：
2021-03-09
影响因子：
11.1
通讯作者：
Verschure PFMJ
中科院分区：
文献类型：
--
作者：
Pacheco Estefan D;Zucca R;Arsiwalla X;Principe A;Zhang H;Rocamora R;Axmacher N;Verschure PFMJ
虽然行为证据表明意志控制的学习有益于人类记忆，但人们对这种效应背后的神经机制知之甚少。啮齿类动物空间导航研究的见解指出了海马体θ振荡的相关性。然而，theta可能支持人类主动学习有益效果的机制目前尚不清楚。在这里，我们证明海马θ振荡增加在意志学习，促进隔离任务相关的代表性信号，根据其语义内容。我们的研究结果构成了一个直接的链接到海马θ振荡及其与意志和记忆过程的动物文献。啮齿动物的电生理学研究表明，主动导航增强海马θ振荡（4-12 Hz），为刺激相关的神经代码提供了一个时间框架。在这里，我们表明，主动学习促进了类似的相位编码制度在人类中，虽然在较低的频率范围（3-8赫兹）。我们分析了癫痫患者的颅内脑电图（iEEG），这些患者在自愿或被动学习条件下研究图像。主动学习增加记忆性能和海马θ振荡，并促进了更准确的刺激特定的信息在记忆检索的再激活。在编码和提取过程中，表征信号被聚集到θ循环的相反相位。重要的是，在主动而非被动学习期间，θ脑内再激活的时间结构反映了刺激的语义相似性，将概念上相似的项目分离到更远的θ阶段。综上所述，这些结果证明了一种多层机制，通过这种机制，主动学习通过遗传学上古老的相位编码方案来改善记忆。
While behavioral evidence shows that volitionally controlled learning benefits human memory, little is known about the neural mechanisms underlying this effect. Insights from spatial navigation research in rodents point to the relevance of hippocampal theta oscillations. However, the mechanisms through which theta might support the beneficial effects of active learning in humans are currently unknown. Here, we demonstrate hippocampal theta oscillations increase during volitional learning, promoting a segregation of task-relevant representational signals according to their semantic content. Our results constitute a direct link to the animal literature on hippocampal theta oscillations and its relation to volition and memory processes. Electrophysiological studies in rodents show that active navigation enhances hippocampal theta oscillations (4–12 Hz), providing a temporal framework for stimulus-related neural codes. Here we show that active learning promotes a similar phase coding regime in humans, although in a lower frequency range (3–8 Hz). We analyzed intracranial electroencephalography (iEEG) from epilepsy patients who studied images under either volitional or passive learning conditions. Active learning increased memory performance and hippocampal theta oscillations and promoted a more accurate reactivation of stimulus-specific information during memory retrieval. Representational signals were clustered to opposite phases of the theta cycle during encoding and retrieval. Critically, during active but not passive learning, the temporal structure of intracycle reactivations in theta reflected the semantic similarity of stimuli, segregating conceptually similar items into more distant theta phases. Taken together, these results demonstrate a multilayered mechanism by which active learning improves memory via a phylogenetically old phase coding scheme.
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影响因子：
9.8
作者：
Kaplan R;Doeller CF;Barnes GR;Litvak V;Düzel E;Bandettini PA;Burgess N
通讯作者：
Burgess N
影响因子：
2.9
作者：
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64.5
作者：
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影响因子：
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作者：
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通讯作者：
Buzsáki, G
影响因子：
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作者：
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Axmacher, Nikolai